Anti-inflammatory activity of phenolic compounds from the whole plant of Scutellaria indica

被引：27

作者：

Cuong, To Dao ^{[1
]}

Hung, Tran Manh ^{[1
]}

Lee, Joo-Sang ^{[1
]}

Weon, Kwon-Yeon ^{[1
]}

Woo, Mi Hee ^{[1
]}

Min, Byung Sun ^{[1
]}

机构：

[1] Catholic Univ Daegu, Coll Pharm, Drug Res & Dev Ctr, Gyeongbuk 712702, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2015年 / 25卷 / 05期

基金：

新加坡国家研究基金会;

关键词：

Scutellaria indica; Labiatae; Flavonoid; Anti-inflammatory activity; RAW; 264.7; cells; NITRIC-OXIDE SYNTHESIS; FLAVANONE GLYCOSIDES; CONSTITUENTS; FLAVONOIDS; MACROPHAGES; MECHANISMS; LABIATAE; CANCER;

D O I：

10.1016/j.bmcl.2014.12.055

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Six new phenolics, scutellariosides A-F (1-3, 5-6, and 8), together with six known compounds (4, 7, 912) were isolated from the whole plant of Scutellaria indica (Labiatae). The chemical structures of these compounds were determined by spectroscopic analyses including 2D NMR. Their anti-inflammatory activities were evaluated against LPS-induced NO production in macrophage RAW 264.7 cells. Among them, compounds 10-12 had inhibitory effects with IC50 values ranging from 7.2 to 27.8 mu M. Compound 12 reduced LPS-induced iNOS expression in a dose-dependent manner. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：1129 / 1134

页数：6

共 50 条

[21] Phenolic compounds from Iris hungarica as potential anti-inflammatory agents
Mykhailenko, Olha
Korinek, Michal
Chen, Bing-Hung
Georgiyants, Victoriya
FREE RADICAL BIOLOGY AND MEDICINE, 2021, 165
[22] Anti-inflammatory activity of phenolic antioxidants.
Huang, MT
Liu, Y
Rosen, RT
Ho, CT
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2004, 228 : U55 - U55
[23] Differential anti-inflammatory effects of phenolic compounds from olive oil identified in human whole blood cultures
Miles, EA
Zoubouli, P
Calder, PC
CHEMISTRY AND PHYSICS OF LIPIDS, 2004, 130 (01) : 34 - 35
[24] Anti-inflammatory compounds from medicinal plant Ruta graveolens
Das, H.
Raghav, S.
Gupta, B.
Das, R. H.
PROCEEDINGS OF THE INTERNATIONAL SYMPOSIUM ON MEDICINAL AND NUTRACEUTICAL PLANTS, 2007, (756): : 389 - 398
[25] ANTI-INFLAMMATORY, ANTI-ARTHRITIC AND ANALGESIC ACTIVITY OF THE ALCOHOLIC EXTRACT OF THE PLANT URGINEA INDICA KUNTH
Rahman, Md. Mominur
Chowdhury, Jakir Ahmed
Habib, Razibul
Saha, Barun Kanti
Salauddin, A. D. M.
Islam, Mohammad Kaisarul
INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 2011, 2 (11): : 2915 - 2919
[26] ANTI-INFLAMMATORY, ANTI-ARTHRITIC AND ANALGESIC ACTIVITY OF THE ALCOHOLIC EXTRACT OF THE PLANT URGINEA INDICA KUNTH
Rahman, Md Mominur
Chowdhury, Jakir Ahmed
Habib, Razibul
Saha, Barun Kanti
Salauddin, A. D. M.
Islam, Mohammad Kaisarul
INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 2011, 2 (09): : 2320 - 2324
[27] Structure and anti-inflammatory activity of neo-clerodane diterpenoids from Scutellaria barbata
Li, ShuTing
Xu, Dan
Jia, Jing
Zou, Wenbo
Liu, JieYing
Wang, Yao
Zhang, Kun
Zheng, Xi
Ma, Yan-Yan
Zhang, Xuejian
Zhao, Deng-Gao
PHYTOCHEMISTRY, 2023, 213
[28] Anti-inflammatory activity of sulfate-containing phenolic compounds isolated from the leaves of Myrica rubra
Kim, Han Hyuk
Oh, Myeong Hwan
Park, Kwang Jun
Heo, Jun Hyeok
Lee, Min Won
FITOTERAPIA, 2014, 92 : 188 - 193
[29] ANTI-INFLAMMATORY ACTIVITY OF WHOLE PLANT OF POLYGALA ROSMARINIFOLIA WIGHT & ARN (POLYGALACEAE)
Alagammal, M.
Nishanthini, A.
Mohan, V. R.
INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 2012, 3 (10): : 3955 - 3957
[30] Withanolides from the whole plant of Physalis angulata and their anti-inflammatory activities
Pham Hai Yen
Le Canh Viet Cuong
Ton That Huu Dat
Dinh Thi Quy Thuy
Dang Thi Ngoc Hoa
Nguyen Thi Cuc
Duong Thi Hai Yen
Do Thi Thao
Hoang Le Tuan Anh
VIETNAM JOURNAL OF CHEMISTRY, 2019, 57 (03) : 334 - 338

← 1 2 3 4 5 →