Anti-inflammatory activity of phenolic compounds from the whole plant of Scutellaria indica

被引：27

作者：

Cuong, To Dao ^{[1
]}

Hung, Tran Manh ^{[1
]}

Lee, Joo-Sang ^{[1
]}

Weon, Kwon-Yeon ^{[1
]}

Woo, Mi Hee ^{[1
]}

Min, Byung Sun ^{[1
]}

机构：

[1] Catholic Univ Daegu, Coll Pharm, Drug Res & Dev Ctr, Gyeongbuk 712702, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2015年 / 25卷 / 05期

基金：

新加坡国家研究基金会;

关键词：

Scutellaria indica; Labiatae; Flavonoid; Anti-inflammatory activity; RAW; 264.7; cells; NITRIC-OXIDE SYNTHESIS; FLAVANONE GLYCOSIDES; CONSTITUENTS; FLAVONOIDS; MACROPHAGES; MECHANISMS; LABIATAE; CANCER;

D O I：

10.1016/j.bmcl.2014.12.055

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Six new phenolics, scutellariosides A-F (1-3, 5-6, and 8), together with six known compounds (4, 7, 912) were isolated from the whole plant of Scutellaria indica (Labiatae). The chemical structures of these compounds were determined by spectroscopic analyses including 2D NMR. Their anti-inflammatory activities were evaluated against LPS-induced NO production in macrophage RAW 264.7 cells. Among them, compounds 10-12 had inhibitory effects with IC50 values ranging from 7.2 to 27.8 mu M. Compound 12 reduced LPS-induced iNOS expression in a dose-dependent manner. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：1129 / 1134

页数：6

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