Mechanisms of Calorie Restriction: A Review of Genes Required for the Life-Extending and Tumor-Inhibiting Effects of Calorie Restriction

被引：20
|
作者：
Komatsu, Toshimitsu [1 ,2 ]
Park, Seongjoon [1 ,2 ]
Hayashi, Hiroko [1 ,2 ]
Mori, Ryoichi [1 ,2 ]
Yamaza, Haruyoshi [3 ]
Shimokawa, Isao [1 ,2 ]
机构：
[1] Nagasaki Univ, Sch Med, Dept Pathol, Nagasaki 8528521, Japan
[2] Nagasaki Univ, Grad Sch Biomed Sci, Nagasaki 8528521, Japan
[3] Kyushu Univ, Fac Dent Sci, Sect Pediat Dent, Div Oral Hlth Growth & Dev,Higashi Ku, 3-1-1 Maidashi, Fukuoka 8128582, Japan
来源：
NUTRIENTS | 2019年 / 11卷 / 12期
关键词：
calorie restriction; FoxO transcription factor; sirtuin; neuropeptide Y; pleiotropy of CR genes; FOXO TRANSCRIPTION FACTORS; NEUROPEPTIDE-Y; DIETARY RESTRICTION; GROWTH-HORMONE; CAENORHABDITIS-ELEGANS; FAMILY-MEMBER; SPAN; LONGEVITY; STRESS; DAF-16;
D O I：
10.3390/nu11123068
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
This review focuses on mechanisms of calorie restriction (CR), particularly the growth hormone (GH)/insulin-like growth factor-1 (IGF-1) axis as an evolutionary conserved signal that regulates aging and lifespan, underlying the effects of CR in mammals. Topics include (1) the relation of the GH-IGF-1 signal with chronic low-level inflammation as one of the possible causative factors of aging, that is, inflammaging, (2) the isoform specificity of the forkhead box protein 0 (FoxO) transcription factors in CR-mediated regulation of cancer and lifespan, (3) the role for Fox01 in the tumor-inhibiting effect of CR, (4) pleiotropic roles for Fox01 in the regulation of disorders, and (5) sirtuin (Sirt) as a molecule upstream of FoxO. From the evolutionary view, the necessity of neuropeptide Y (Npy) for the effects of CR and the pleiotropic roles for Npy in life stages are also emphasized. Genes for mediating the effects of CR and regulating aging are context-dependent, particularly depending on nutritional states.
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页数：18
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