Mechanisms of Calorie Restriction: A Review of Genes Required for the Life-Extending and Tumor-Inhibiting Effects of Calorie Restriction

被引：20

作者：

Komatsu, Toshimitsu ^{[1
,2
]}

Park, Seongjoon ^{[1
,2
]}

Hayashi, Hiroko ^{[1
,2
]}

Mori, Ryoichi ^{[1
,2
]}

Yamaza, Haruyoshi ^{[3
]}

Shimokawa, Isao ^{[1
,2
]}

机构：

[1] Nagasaki Univ, Sch Med, Dept Pathol, Nagasaki 8528521, Japan

[2] Nagasaki Univ, Grad Sch Biomed Sci, Nagasaki 8528521, Japan

[3] Kyushu Univ, Fac Dent Sci, Sect Pediat Dent, Div Oral Hlth Growth & Dev,Higashi Ku, 3-1-1 Maidashi, Fukuoka 8128582, Japan

来源：

NUTRIENTS | 2019年 / 11卷 / 12期

关键词：

calorie restriction; FoxO transcription factor; sirtuin; neuropeptide Y; pleiotropy of CR genes; FOXO TRANSCRIPTION FACTORS; NEUROPEPTIDE-Y; DIETARY RESTRICTION; GROWTH-HORMONE; CAENORHABDITIS-ELEGANS; FAMILY-MEMBER; SPAN; LONGEVITY; STRESS; DAF-16;

D O I：

10.3390/nu11123068

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

This review focuses on mechanisms of calorie restriction (CR), particularly the growth hormone (GH)/insulin-like growth factor-1 (IGF-1) axis as an evolutionary conserved signal that regulates aging and lifespan, underlying the effects of CR in mammals. Topics include (1) the relation of the GH-IGF-1 signal with chronic low-level inflammation as one of the possible causative factors of aging, that is, inflammaging, (2) the isoform specificity of the forkhead box protein 0 (FoxO) transcription factors in CR-mediated regulation of cancer and lifespan, (3) the role for Fox01 in the tumor-inhibiting effect of CR, (4) pleiotropic roles for Fox01 in the regulation of disorders, and (5) sirtuin (Sirt) as a molecule upstream of FoxO. From the evolutionary view, the necessity of neuropeptide Y (Npy) for the effects of CR and the pleiotropic roles for Npy in life stages are also emphasized. Genes for mediating the effects of CR and regulating aging are context-dependent, particularly depending on nutritional states.

引用

页数：18

共 47 条

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