Does single-strand DNA break repair capacity influence oocyte maintenance and quality?

被引：0

作者：

Giridharan, Saranya ^{[1
]}

Hutt, Karla J. ^{[1
]}

Winship, Amy L. ^{[1
]}

机构：

[1] Monash Univ, Biomed Discovery Inst, Dept Anat & Dev Biol, Ovarian Biol Lab,Dev & Stem Cells Program, Clayton, Vic, Australia

来源：

REPRODUCTION | 2022年 / 164卷 / 06期

基金：

澳大利亚研究理事会;

关键词：

INTEGRITY;

D O I：

10.1530/REP-22-0325

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Human genome-wide association studies and evidence from animal models link ovarian ageing to double-strand (ds)DNA break repair capacity. Is there a connection between single-strand (ss)DNA repair mechanisms and ovarian function? We hypothesize that endogenous cellular processes subject oocytes to ssDNA lesions, and thus, ssDNA repair capacity is fundamental to their survival and maintenance.

引用

页码：V15 / V18

页数：4

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