Synthesis, Isolation and Characterization of Process-Related Impurities in Oseltamivir Phosphate

被引：3
|
作者：
Sharma, Yogesh Kumar [1 ]
Agarwal, Dau Dayal [2 ]
Bhure, Sudesh [2 ]
Rathore, Sanjay Singh [2 ]
Rawat, Chakravir [2 ]
Mukharjee, Rajendranath [2 ]
机构：
[1] Jiwaji Univ, Dept Ind Chem, Gwalior 475011, Madhya Pradesh, India
[2] Pharmasolve Special I Pvt Ltd, Bombay, Maharashtra, India
来源：
E-JOURNAL OF CHEMISTRY | 2012年 / 9卷 / 01期
关键词：
Oseltamivir phosphate; Impurities; Synthesis; Isolation and Characterization; ANTIMALARIALS; ARTESUNATE;
D O I：
10.1155/2012/327351
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Three known impurities in oseltamivir phosphate bulk drug at level 0.1% (ranging from 0.05-0.1%) were detected by gradient reverse phase high performance liquid chromatography. These impurities were preliminarily identified by the mass number of the impurities. Different experiments were conducted and finally the known impurities were synthesized and characterized.
引用
收藏
页码：113 / 120
页数：8
相关论文
共 50 条
  • [21] Isolation and characterization of degradation products of citalopram and process-related impurities using RP-HPLC
    Rao, Ramisetti Nageswara
    Raju, Ale Narasa
    Narsimha, Ramaram
    JOURNAL OF SEPARATION SCIENCE, 2008, 31 (10) : 1729 - 1738
  • [22] Identification, characterization, synthesis and HPLC quantification of new process-related impurities and degradation products in retigabine
    Dousa, Michal
    Srbek, Jan
    Radl, Stanislav
    Cerny, Josef
    Klecan, Ondrej
    Havlicek, Jaroslav
    Tkadlecova, Marcela
    Pekarek, Tomas
    Gibala, Petr
    Novakova, Lucie
    JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2014, 94 : 71 - 76
  • [23] Isolation, identification and structure elucidation of two novel process-related impurities of retigabine
    Zhang, Dengfeng
    Song, Xin
    Su, Jiangtao
    JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2014, 99 : 22 - 27
  • [24] Identification, Characterization, and Quantification of Impurities of Safinamide Mesilate: Process-Related Impurities and Degradation Products
    Zou, Liang
    Sun, Lili
    Zhang, Hui
    Hui, Wenkai
    Zou, Qiaogen
    Zhu, Zheying
    JOURNAL OF AOAC INTERNATIONAL, 2017, 100 (04) : 1029 - 1037
  • [25] Identification, characterization, and synthesis of process-related impurities in antiproliferative agent TQ-B3203
    Zhang, Xiquan
    Cao, Meng
    Xing, Jing
    Zheng, Ming
    Liu, Fei
    Dong, Ping
    Tian, Xin
    Xu, Hongjiang
    Zhang, Laifang
    Gu, Hongmei
    Yang, Ling
    Li, Rui
    Ji, Min
    Gu, Ning
    JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES, 2016, 39 (10) : 488 - 496
  • [26] Identification, synthesis and structural confirmation of process-related impurities in proparacaine hydrochloride
    Yang, Zixin
    Zhao, Jiaxing
    Feng, Yao
    Lei, Yu
    Liu, Dan
    Qin, Feng
    Zheng, Jiang
    Wang, Shaojie
    JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2020, 190
  • [27] Four process-related potential new impurities in ticagrelor: Identification, isolation, characterization using HPLC, LC/ESI-MSn, NMR and their synthesis
    Kumar, Neeraj
    Devineni, Subba Rao
    Gajjala, Prasad Reddy
    Gupta, Dharmendra Kumar
    Bhat, Sandesh
    Kumar, Rajesh
    Dubey, Shailendra Kumar
    Kumar, Pramod
    JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2016, 120 : 248 - 260
  • [28] Synthesis and control of process-related impurities in the β-lactamase inhibitor drug substance zidebactam
    Pund, Amit A.
    Rane, Vipul P.
    Raut, Vivek T.
    Ahirrao, Vinod K.
    Yeole, Ravindra D.
    Joshi, Sanjeev
    Bhavsar, Satish
    Rafeeq, Mohammad
    Yadav, Ramprasad
    Merwade, Arvind Y.
    SYNTHETIC COMMUNICATIONS, 2023, 53 (13) : 1041 - 1052
  • [29] Identification, isolation and characterization of process related impurities in ezetimibe
    Guntupalli, Srikanth
    Ray, Uttam Kumar
    Murali, N.
    Gupta, P. Badrinadh
    Kumar, Vundavilli Jagadeesh
    Satheesh, D.
    Islam, Aminul
    JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2014, 88 : 385 - 390
  • [30] Identification, Synthesis, and Control of Process-Related Impurities in the Antipsychotic Drug Substance Brexpiprazole
    Tyagi, Rahul
    Singh, Harnam
    Singh, Jagat
    Arora, Himanshu
    Yelmeli, Vijayalaxmi
    Jain, Mohit
    Girigani, Sathyanarayana
    Kumar, Pramod
    ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2018, 22 (11) : 1471 - 1480
12345