Synthesis, Isolation and Characterization of Process-Related Impurities in Oseltamivir Phosphate

被引：3
|
作者：
Sharma, Yogesh Kumar [1 ]
Agarwal, Dau Dayal [2 ]
Bhure, Sudesh [2 ]
Rathore, Sanjay Singh [2 ]
Rawat, Chakravir [2 ]
Mukharjee, Rajendranath [2 ]
机构：
[1] Jiwaji Univ, Dept Ind Chem, Gwalior 475011, Madhya Pradesh, India
[2] Pharmasolve Special I Pvt Ltd, Bombay, Maharashtra, India
来源：
E-JOURNAL OF CHEMISTRY | 2012年 / 9卷 / 01期
关键词：
Oseltamivir phosphate; Impurities; Synthesis; Isolation and Characterization; ANTIMALARIALS; ARTESUNATE;
D O I：
10.1155/2012/327351
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Three known impurities in oseltamivir phosphate bulk drug at level 0.1% (ranging from 0.05-0.1%) were detected by gradient reverse phase high performance liquid chromatography. These impurities were preliminarily identified by the mass number of the impurities. Different experiments were conducted and finally the known impurities were synthesized and characterized.
引用
收藏
页码：113 / 120
页数：8
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