Immunosuppressive Effects of Multipotent Mesenchymal Stromal Cells in Cultures with Different O2 Content in the Medium

被引：5
|
作者：
Gornostaeva, A. N. [1 ]
Andreeva, E. R. [1 ]
Andrianova, I. V. [1 ]
Buravkova, L. B. [1 ]
机构：
[1] Russian Acad Sci, Inst Biomed Problems, Moscow 117901, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2011年 / 151卷 / 04期
关键词：
multipotent mesenchymal stromal cells; immunocompetent cells; low partial oxygen pressure; co-culturing; proliferative index; STEM-CELLS; T-LYMPHOCYTES; PERIPHERAL-BLOOD; OXYGEN-TENSION; PROLIFERATION; EXPRESSION; CYTOKINE; PROMOTE; TISSUE;
D O I：
10.1007/s10517-011-1372-2
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We studied the effects of multipotent mesenchymal stromal cells isolated from the adipose tissue on proliferation and viability of immunocompetent cells at different concentration of O-2 (5 and 20%) in culture medium. It was shown that co-culturing with multipotent mesenchymal stromal cells 3-fold reduced proliferative index of phytohemagglutinin-activated lymphocytes, while their viability remained unchanged and did not depend on partial oxygen pressure in the medium. These findings suggest that low O-2 concentration in tissues will not affect immunosuppressive properties of multipotent mesenchymal stromal cells, which is very important for their application in regenerative medicine.
引用
收藏
页码：526 / 529
页数：4
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