Mitochondrial Protection by Resveratrol

被引：87

作者：

Ungvari, Zoltan ^{[1
,2
]}

Sonntag, William E. ^{[1
,2
]}

de Cabo, Rafael ^{[3
]}

Baur, Joseph A. ^{[4
,5
]}

Csiszar, Anna ^{[1
,2
]}

机构：

[1] Univ Oklahoma, Hlth Sci Ctr, Reynolds Oklahoma Ctr Aging, Dept Geriatr Med, Oklahoma City, OK 73104 USA

[2] Univ Oklahoma, Hlth Sci Ctr, Dept Physiol, Oklahoma City, OK 73104 USA

[3] NIA, Lab Expt Gerontol, NIH, Baltimore, MD 21224 USA

[4] Univ Penn, Raymond & Ruth Perelman Sch Med, Inst Diabet Obes & Metab, Philadelphia, PA 19104 USA

[5] Univ Penn, Raymond & Ruth Perelman Sch Med, Dept Physiol, Philadelphia, PA 19104 USA

来源：

EXERCISE AND SPORT SCIENCES REVIEWS | 2011年 / 39卷 / 03期

基金：

美国国家卫生研究院;

关键词：

senescence; bioenergetics; mitochondria; aging; caloric restriction; cardiovascular disease; phytochemicals; SMALL-MOLECULE ACTIVATORS; LIFE-SPAN; CALORIE RESTRICTION; OXIDATIVE STRESS; SKELETAL-MUSCLE; IN-VIVO; ENDOTHELIAL-CELLS; SIRT1; BIOGENESIS; MICE;

D O I：

10.1097/JES.0b013e3182141f80

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

UNGVARI, Z., W. E. SONNTAG, R. DE CABO, J.A. BAUR, and A. CSISZAR. Mitochondrial protection by resveratrol. Exerc. Sport. Sci. Rev., Vol. 39, No. 3, pp. 128-132, 2011. Mitochondrial dysfunction and oxidative stress are thought to play important roles in mammalian aging. Resveratrol is a plant-derived polyphenol that exerts diverse antiaging activities, mimicking some of the molecular and functional effects of dietary restriction. This review focuses on the molecular mechanisms underlying the mitochondrial protective effects of resveratrol, which could be exploited for the prevention or amelioration of age-related diseases in the elderly.

引用

页码：128 / 132

页数：5

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