Analysis of weak UV-absorbing pharmaceutical drug substances using CE with condensation nucleation light-scattering detection

被引：0
|
作者：
Lytle, ML
Magnusson, LE
Guo, W
Koropchak, JA
Risley, DS
机构：
[1] Eli Lilly & Co, Lilly Corp Ctr, Indianapolis, IN 46285 USA
[2] So Illinois Univ, Dept Chem & Biochem, Carbondale, IL 62901 USA
来源：
LC GC NORTH AMERICA | 2001年 / 19卷 / 06期
关键词：
D O I：
暂无
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The authors developed new analytical methodology to determine three pharmaceutical drug substances - LY354740, LY293558, and LY235959 using capillary electrophoresis (CE) with condensation nucleation light-scattering detection. This CE-condensation nucleation light-scattering detection system can perform trace analysis for these drug substances, which tack sufficient ultraviolet chromophores. The authors obtained acceptable levels of precision, linearity, and limit of detection for these compounds using the CE-condensation nucleation light-scattering detection system.
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页码：624 / +
页数：5
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