Rhodium-Catalyzed Direct Arylation of Furopyridine: Synthesis and the Cardiac Effects of Dictamnine Derivatives

被引：8

作者：

Du, Yufeng ^{[1
]}

Huang, Linyu ^{[1
]}

Wang, Neng ^{[1
]}

Li, Xiaohuan ^{[1
]}

Zhou, Xian-Li ^{[1
]}

Zhang, Lan ^{[1
]}

Huang, Shuai ^{[1
]}

Walsh, Patrick J. ^{[2
]}

Gao, Feng ^{[1
]}

机构：

[1] Southwest Jiaotong Univ, Sch Life Sci & Engn, 111 Erhuan Rd, Chengdu 610031, Peoples R China

[2] Univ Penn, Dept Chem, Roy & Diana Vagelos Labs, 231 South 34th St, Philadelphia, PA 19104 USA

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2022年 / 364卷 / 05期

基金：

中国国家自然科学基金; 美国国家科学基金会;

关键词：

dictamnine; furopyridine; rhodium; C-H functionalization; C BOND FORMATION; ARYL; HETEROCYCLES; SYSTEM; MILD;

D O I：

10.1002/adsc.202101421

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Herein is reported a Rh-2(OAc)(4)/IMes . HCl system that promotes the chemoselective installation of aryl groups at the 2-position of furo[2,3-b]pyridine (53-94% yields). The method is applicable to the direct modification of the natural furoquinoline alkaloid dictamnine. The cardiac effects of the fluorinated analogues improved, compared to dictamnine at 160 mu g/mL. Preliminary mechanism of action studies indicate that the effects might be related to epinephrine alpha receptors, M-receptor, and calcium channel receptor.

引用

页码：1002 / 1008

页数：7

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