Synthesis and Anticancer Properties of Rare Earth Substituted Tungstophosphoric Polyoxometalate Containing 5-Fluorouracil

Three novel rare earth substituted polyoxometalates containing 5-fluorouracil, K10C4H4FN2O2Pr(PW11O39)(2)center dot 24H(2)O, K10C4H4FN2O2Nd(PW11O39)(2)center dot 12H(2)O and K10C4H4FN2O2Sm(PW11O39)(2)center dot 12.5H(2)O were synthesized and structurally characterized by elemental analysis, IR spectra, X-ray powder diffraction and W-183 NMR. The results indicate that the compounds have Keggin structure of heteropolyanion and ring structure of 5-fluorouracil. The cytotoxicity test of the compounds in human renal embryonic cell HEK293 and the activity inhibiting human cervical carcinoma cell Hela were studied by the methyl thiazolyl tetrazolium method with 5-fluorouracil for the positive control group. The toxicity of the compounds are lower than that of 5-fluorouracil. K10C4H4FN2O2Pr(PW11O39)(2)center dot 24H(2)O has no apparent toxicity in vitro and can inhibit Hela cells in vitro with significant difference compared with 5-Fu.