Anti-IL-12 MAb suppresses memory Th1 responses and is active in animal models of autoimmunity

被引:0
|
作者
Banerjee, S
Waegell, W
Veidman, T
Wysocke, M
Trinchieri, G
Salfeld, J
Tracey, D
机构
[1] BASF Biores Corp, Worcester, MA 01605 USA
[2] Genet Inst, Cambridge, MA 02140 USA
[3] Wistar Inst, Philadelphia, PA 19104 USA
来源
ARTHRITIS AND RHEUMATISM | 1998年 / 41卷 / 09期
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
33
引用
收藏
页码:S38 / S38
页数:1
相关论文
共 50 条
  • [41] Activated neutrophils promote TH1 polarization in active ANCA-associated vasculitis and sepsis by producing IL-12 and IL-18.
    Bank, U
    Ansorge, S
    Neumann, KH
    Wrenger, E
    [J]. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2002, 13 : 177A - 177A
  • [42] Effector-Phase IL-2 Signals Drive Th1 Effector and Memory Responses Dependently and Independently of TCF-1
    Charley, Krystal R.
    Ramstead, Andrew G.
    Matous, Joseph G.
    Kumaki, Yohichi
    Sircy, Linda M.
    Hale, J. Scott
    Williams, Matthew A.
    [J]. JOURNAL OF IMMUNOLOGY, 2024, 212 (04): : 586 - 595
  • [43] Opposing effects of the IL12B and IL23R psoriasis associated risk alleles on Th1 and Th17 responses in psoriatic skin
    Xing, X.
    Johnston, A.
    Swindell, W. R.
    Stuart, P. R.
    Nair, R. P.
    Voorhees, J. J.
    Elder, J. T.
    Gudjonsson, J. E.
    [J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2013, 133 : S41 - S41
  • [44] IL12p35 but not IL12-p40deficient mice have functional Th1 responses to primary and secondary infection with Histoplasma Capsulatum
    Zhou, P
    Freidag, B
    Seder, R
    [J]. FASEB JOURNAL, 2000, 14 (06): : A980 - A980
  • [45] IL-2IC SUPPRESSES CIA IN MICE BY THE TH1/TH17 IMMUNE RESPONSES DUE TO ENHANCEMENT OF BOTH TREG NUMBERS AND TREG FUNCTIONS
    Yokoyama, Y.
    Iwasaki, T.
    Kitano, S.
    Furukawa, T.
    Satake, A.
    Matsui, K.
    Sano, H.
    [J]. ANNALS OF THE RHEUMATIC DISEASES, 2017, 76 : 210 - 210
  • [46] Aluminium adjuvants potently inhibit the secretion of IL-12 which may explain their poor efficacy in promoting Th1 responses
    Oleszycka, E.
    Mori, A.
    Lavelle, E. C.
    [J]. IMMUNOLOGY, 2011, 135 : 90 - 90
  • [47] Chronic stimulation of dendritic cells with ATP results in impaired production of IL-12 and reduced ability to initiate Th1 responses
    la Sala, A
    Ferrari, D
    Corinti, S
    Cavani, A
    Di Virgilio, F
    Girolomoni, G
    [J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2000, 115 (03) : 569 - 569
  • [48] IL-12 induces Th1 responses but does not prevent vaccine-enhanced illness during viral challenge.
    Openshaw, P
    Khan, U
    Hussell, T
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1997, 99 (01) : 1496 - 1496
  • [49] IL-10 Regulates Memory T Cell Development and the Balance between Th1 and Follicular Th Cell Responses during an Acute Viral Infection
    Tian, Yuan
    Mollo, Sarah B.
    Harrington, Laurie E.
    Zajac, Allan J.
    [J]. JOURNAL OF IMMUNOLOGY, 2016, 197 (04): : 1308 - 1321
  • [50] Hepatitis C virus non-structural protein 4 suppresses Th1 responses by stimulating IL-10 production from monocytes
    Brady, MT
    MacDonald, AJ
    Rowan, AG
    Mills, KHG
    [J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 2003, 33 (12) : 3448 - 3457