NF-κB-inducing kinase regulates the processing of NF-κB2 p100

被引：703
|
作者：
Xiao, GT [1 ]
Harhaj, EW [1 ]
Sun, SC [1 ]
机构：
[1] Penn State Univ, Coll Med, Dept Microbiol & Immunol, Hershey, PA 17033 USA
来源：
MOLECULAR CELL | 2001年 / 7卷 / 02期
关键词：
D O I：
10.1016/S1097-2765(01)00187-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Processing of the nf kappa b2 gene product p100 to generate p52 is an important step in NF-kappaB regulation. We show that this step is negatively regulated by a processing-inhibitory domain (PID) within p100 and positively regulated by the NF-kappaB-inducing kinase (NIK). While the PID suppresses the constitutive processing of p100, NIK induces p100 processing by stimulating site-specific phosphorylation and ubiquitination of this precursor protein. Further, a natural mutation of the gene encoding NIK in alymphoplasia (aly) mice cripples the function of NIK in p100 processing, causing a severe defect in p52 production. These data suggest that NIK is a specific kinase regulating p100 processing and explain why the aly and nf kappa b2 knockout mice exhibit similar immune deficiencies.
引用
收藏
页码：401 / 409
页数：9
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