Prophylactic thyroidectomy in the treatment of thyroid medullary carcinoma. age for surgery?

被引：5
|
作者：
Hassett, S
Costigan, C
McDermott, M
Fitzgerald, RJ
机构：
[1] Our Ladys Hosp Sick Children, Dept Paediat Surg, Dublin, Ireland
[2] Our Ladys Hosp Sick Children, Dept Pathol, Dublin, Ireland
来源：
EUROPEAN JOURNAL OF PEDIATRIC SURGERY | 2000年 / 10卷 / 05期
关键词：
medullary thyroid carcinoma; thyroidectomy;
D O I：
10.1055/s-2008-1072386
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Since the association of RET proto-oncogene mutations and medullary thyroid carcinoma in children there has been much discussion regarding timing of surgery. Our study group was formed from a brother and sister (8 and 5) and 3 brothers (9, 13, 16) selected on the basis of a positive family history for thyroid medullary carcinoma. Histological examinations of the thyroidectomy specimens showed that the 8- and 9-year old had microinvasive carcinoma and the remaining three had C-cell hyperplasia. Our recommendation is for prophylactic thyroidectomy for children with RET proto oncogene mutations at an early age, clearly before age 5.
引用
收藏
页码：334 / 336
页数：3
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