Type II phosphatidylinositol 4-kinase(s) in cell signaling cascades

被引：0

作者：

Sinha, Ranjeet Kumar ^{[1
]}

Subrahmanyam, Gosukonda ^{[1
]}

机构：

[1] Indian Inst Technol, Biotechnol Grp, Sch Biosci & Bioengn, Bombay 400076, Maharashtra, India

来源：

INDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS | 2007年 / 44卷 / 05期

关键词：

lipid kinases; cell signaling; cytoskeleton; cell adhesion; microbial pathogenicity;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phosphorylated derivatives of phosphatidylinositol (PtdIns) are key components of many signaling cascades. Many isoforms of PtdIns kinases, PtdIns phosphate kinases and phosphatases use these lipids in amazing networks of signaling cascades that are yet to be understood fully. PtdIns 4-kinase(s) phosphorylates PtdIns at the 4(th)-OH position of inositol head group and are classified in to type II and III PtdIns 4-kinases. While type III PtdIns 4-kinases are implicated in vesicular trafficking, type II PtdIns 4-kinases are suggested to play a role in cell signaling, cytoskeletal rearrangements, cell motility and in microbial pathogenicity. This paper reviews the role of type II PtdIns 4-kinases in cell signaling cascades in health and disease.

引用

页码：289 / 294

页数：6

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