Exploiting DNA damage without repair: The activity of platinum chemotherapy in BRCA-mutated prostate cancers

被引：6
|
作者：
Humeniuk, Michael S. [1 ]
Zhang, Tian [1 ,2 ]
Armstrong, Andrew J. [2 ,3 ,4 ,5 ]
机构：
[1] Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA
[2] Duke Canc Inst, Durham, NC USA
[3] Duke Univ, Med Ctr, Dept Med, Div Med Oncol, Durham, NC 27710 USA
[4] Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA
[5] Duke Univ, Dept Pharmacol & Canc Biol, Durham, NC USA
来源：
CANCER | 2017年 / 123卷 / 18期
关键词：
MEN; SURVIVAL;
D O I：
10.1002/cncr.30806
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The report in this issue by Pomerantz and colleagues demonstrates that men with metastatic prostate cancer harboring germline BRCA2 mutations are strongly associated with a prostate-specific antigen response 50% during treatment with a platinum agent. However, more work will be required to classify other men who might benefit from platinum agents. See also pages 3532-9.
引用
收藏
页码：3441 / 3444
页数：4
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