Dissection and rational engineering of the biosynthetic pathway to enacyloxin, a promising anti-Gram-negative antibiotic

被引：0
|
作者：
Masschelein, J. [1 ]
Sydor, P. K. [1 ]
Griffiths, D. [1 ]
Valentic, T. R. [2 ,3 ,4 ]
Gallo, A. [1 ]
Jones, C. [5 ]
Song, L. [1 ]
Tsai, S. C. [2 ,3 ,4 ]
Lewandowski, J. R. [1 ]
Mahenthiralingam, E. [5 ]
Challis, G. L. [1 ]
机构：
[1] Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England
[2] Univ Calif Irvine, Dept Mol Biol & Biochem, Irvine, CA 92697 USA
[3] Univ Calif Irvine, Dept Chem, Irvine, CA 92697 USA
[4] Univ Calif Irvine, Dept Pharmaceut Sci, Irvine, CA 92697 USA
[5] Cardiff Univ, Cardiff Sch Biosci, Organisms & Environm Div, Cardiff CF10 3AT, S Glam, Wales
来源：
PLANTA MEDICA | 2016年 / 82卷
基金：
英国生物技术与生命科学研究理事会;
关键词：
Synthetic biology; enzymology; polyketide biosynthesis; Burkholderia; antibiotic; BACTERIA; IIA; BINDING; TU;
D O I：
10.1055/s-0036-1596129
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
SL22
引用
收藏
页数：2
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