Single-molecule fluorescence spectroscopy of protein folding

被引：123
|
作者：
Schuler, B [1 ]
机构：
[1] Univ Zurich, Dept Biochem, CH-8057 Zurich, Switzerland
来源：
CHEMPHYSCHEM | 2005年 / 6卷 / 07期
关键词：
emission spectroscopy; FRET (fluorescence resonance energy transfer); protein folding; proteins; single-molecule studies;
D O I：
10.1002/cphc.200400609
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Single-molecule spectroscopy is an important new approach for studying the intrinsically heterogeneous process of protein folding. This Review illustrates how different single-molecule fluorescence techniques have improved our understanding of mechanistic aspects in protein folding, exemplified by a series of recent experiments on a small protein.
引用
收藏
页码：1206 / 1220
页数：15
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