Prognostic Value of E-Cadherin Expression and CDH1 Promoter Methylation in Patients With Endometrial Carcinoma

被引：32
|
作者：
Yi, Tie-Zhong [1 ]
Guo, Jing [2 ]
Zhou, Lili [3 ]
Chen, Xing [4 ]
Mi, Ruo-Ran [5 ]
Qu, Quan-Xin [6 ]
Zheng, Jian-Hua [1 ]
Zhai, Ling [1 ]
机构：
[1] Harbin Med Univ, Affiliated Hosp 1, Dept Obstet & Gynecol, Harbin 150001, Peoples R China
[2] Qiqihaer Jianhua Hosp, Dept Obstet & Gynecol, Qiqihar, Peoples R China
[3] Heilongjiang Provincal Hosp, Dept Obstet & Gynecol, Harbin, Peoples R China
[4] Taizhou Hosp, Dept Obstet & Gynecol, Taizhou, Zhejiang, Peoples R China
[5] Tianjin Med Univ, Gen Hosp, Dept Obstet & Gynecol, Tianjin, Peoples R China
[6] Tianjin First Cent Hosp, Dept Obstet & Gynecol, Tianjin, Peoples R China
来源：
CANCER INVESTIGATION | 2011年 / 29卷 / 01期
关键词：
CELL-ADHESION; TUMOR DEDIFFERENTIATION; GENE-EXPRESSION; DNA METHYLATION; CANCER; HYPERMETHYLATION; MOLECULES; INACTIVATION; REPRESSOR; DISEASE;
D O I：
10.3109/07357907.2010.512603
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The primary aim of this study is to evaluate the clinical significance of E-cadherin protein expression and the methylation status in CDH1 promoter in endometrial cancer. The expression of E-cadherin and methylation in its promoter region was analyzed, retrospectively, in 152 clinical tissue samples from patients with endometrial lesions. We found that the hypermethylation of CDH1 promoter, which caused low expression of E-cadherin in endometrial cancer, was associated with not only clinicopathological progress of endometrial cancer but also with the overall 5-year clinical survival rate. The findings provide the potential therapeutic and prognostic target molecule for patients with endomethrial cancer.</.
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页码：86 / 92
页数：7
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