Adsorption of viral particles from the blood plasma of patients with viral hepatitis on nanodiamonds

被引：7
|
作者：
Baron, A. V. [1 ,2 ]
Osipov, N. V. [3 ]
Yashchenko, S. V. [3 ]
Kokotukha, Yu. A. [3 ]
Baron, I. J. [4 ]
Puzyr, A. P. [1 ]
Olkhovskiy, I. A. [5 ,6 ]
Bondar, V. S. [1 ]
机构：
[1] Russian Acad Sci, Siberian Branch, Inst Biophys, Krasnoyarsk 660036, Russia
[2] Siberian Fed Univ, Svobodnyi Pr 79, Krasnoyarsk 660041, Russia
[3] Krasnoyarsk Reg Ctr Prevent & Control AIDS, Ul Karla Marksa 47, Krasnoyarsk 660049, Russia
[4] Voino Yasenetskii State Med Univ, Minist Hlth Russian Federat, Ul Partizana Zheleznyaka 1, Krasnoyarsk 660022, Russia
[5] Minist Hlth Russian Federat, Krasnoyarsk Branch, Hematol Res Ctr, Krasnoyarsk, Russia
[6] Russian Acad Sci, Siberian Branch, Krasnoyarsk Res Ctr, Krasnoyarsk 630036, Russia
来源：
DOKLADY BIOCHEMISTRY AND BIOPHYSICS | 2016年 / 469卷 / 01期
关键词：
D O I：
10.1134/S1607672916040037
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Adsorption of viral particles from the blood plasma of patients with viral hepatitis B and C on modified nanodiamonds (MNDs) was shown in the in vitro experiments. PCR method showed the treatment of plasma with MNDs leads to a decrease in the viral load by 2-3 orders of magnitude or more in both cases studied. These results make it possible to predict the applicability of MNDs for the development of new technologies of hemodialysis and plasmapheresis for binding and removal of viral particles from the blood of infected patients.
引用
收藏
页码：244 / 246
页数：3
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