GENETICS Mapping autoimmune disease epigenetics: what's on the horizon?

被引：7
|
作者：
Brown, Chrysothemis C. [1 ]
Wedderburn, Lucy R. [2 ]
机构：
[1] Kings Coll London, Div Transplantat Immunol & Mucosal Biol, London SE1 9RT, England
[2] UCL Inst Child Hlth, Infect Immun Inflammat & Physiol Med Programme, London WC1N 1EH, England
来源：
NATURE REVIEWS RHEUMATOLOGY | 2015年 / 11卷 / 03期
基金：
英国惠康基金;
关键词：
T-CELLS; SUSCEPTIBILITY; POLARIZATION; ENHANCERS; ARTHRITIS;
D O I：
10.1038/nrrheum.2014.210
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Can a patient's genotype provide insight into the mechanistic basis of autoimmune disease? A study integrating epigenetic data with finely mapped disease-associated variants sheds light on how noncoding variants might alter gene expression within specific immune cells, and hints at new possibilities for individualizing treatment of autoimmune rheumatic disorders.
引用
收藏
页码：131 / U20
页数：2
相关论文
共 50 条
  • [31] The Genetics of Autoimmune Thyroid Disease
    Weetman, A. P.
    HORMONE AND METABOLIC RESEARCH, 2009, 41 (06) : 421 - 425
  • [32] Autoimmune Disease Genetics 2013
    Niewold, Timothy B.
    Goulielmos, George N.
    Assassi, Shervin
    JOURNAL OF IMMUNOLOGY RESEARCH, 2014, 2014
  • [33] The genetics of autoimmune thyroid disease
    Ayadi, H
    Kacem, HH
    Rebai, A
    Farid, NR
    TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2004, 15 (05): : 234 - 239
  • [34] Unraveling the genetics of autoimmune disease
    Timothy J. Vyse
    Nature Reviews Rheumatology, 2009, 5 : 187 - 188
  • [35] Genetics of autoimmune liver disease
    Donaldson, PT
    IMMUNOLOGY & LIVER, 2000, 114 : 115 - 132
  • [36] The genetics of autoimmune thyroid disease
    Vaidya, B
    Kendall-Taylor, P
    Pearce, SHS
    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2002, 87 (12): : 5385 - 5397
  • [37] The genetics of human autoimmune disease
    Invernizzi, Pietro
    Gershwin, M. Eric
    JOURNAL OF AUTOIMMUNITY, 2009, 33 (3-4) : 290 - 299
  • [38] Unraveling the genetics of autoimmune disease
    Vyse, Timothy J.
    NATURE REVIEWS RHEUMATOLOGY, 2009, 5 (04) : 187 - 188
  • [39] What's on the horizon
    Ajluni, C
    ELECTRONIC DESIGN, 1997, 45 (05) : 60 - 60
  • [40] What's on the horizon?
    Ferguson, Maria
    PHI DELTA KAPPAN, 2018, 99 (06) : 72 - 73
12345