GENETICS Mapping autoimmune disease epigenetics: what's on the horizon?

被引：7
|
作者：
Brown, Chrysothemis C. [1 ]
Wedderburn, Lucy R. [2 ]
机构：
[1] Kings Coll London, Div Transplantat Immunol & Mucosal Biol, London SE1 9RT, England
[2] UCL Inst Child Hlth, Infect Immun Inflammat & Physiol Med Programme, London WC1N 1EH, England
来源：
NATURE REVIEWS RHEUMATOLOGY | 2015年 / 11卷 / 03期
基金：
英国惠康基金;
关键词：
T-CELLS; SUSCEPTIBILITY; POLARIZATION; ENHANCERS; ARTHRITIS;
D O I：
10.1038/nrrheum.2014.210
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Can a patient's genotype provide insight into the mechanistic basis of autoimmune disease? A study integrating epigenetic data with finely mapped disease-associated variants sheds light on how noncoding variants might alter gene expression within specific immune cells, and hints at new possibilities for individualizing treatment of autoimmune rheumatic disorders.
引用
收藏
页码：131 / U20
页数：2
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