Role of Progenitor Cells in Liver Regeneration after Subtotal Resection

被引：3
|
作者：
El'chaninov, A. V. [1 ,2 ,3 ]
Fatkhudinov, T. Kh. [1 ,2 ,3 ]
Kananykhina, E. Yu. [1 ,2 ]
Usman, N. Yu. [1 ,2 ]
Arutyunyan, I. V. [1 ,2 ]
Makarov, A. V. [1 ,2 ,3 ]
Bykov, A. V. [3 ]
Bolshakova, G. V. [2 ]
Sukhikh, G. T. [1 ]
机构：
[1] Minist Hlth Russian Federat, VI Kulakov Res Ctr Obstet Gynecol & Perinatol, Moscow, Russia
[2] Inst Human Morphol, Moscow, Russia
[3] NI Pirogov Russian State Med Univ, Minist Hlth Russian Federat, Moscow, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2016年 / 161卷 / 01期
基金：
俄罗斯基础研究基金会;
关键词：
liver; regeneration; subtotal resection; progenitor cells; FATE;
D O I：
10.1007/s10517-016-3367-5
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
In the liver of rats subjected to subtotal liver resection (80% organ weight), the expression of sox9 gene and SOX9 protein content increased and cells with hepatocyte morphology expressing SOX9 appeared; the proportion of cells expressing cytokeratin-19 also increased. Based on these data, we cannot completely exclude the involvement of resident progenitor cells and hepatocyte reprogramming in liver regeneration after subtotal resection, however, the contribution of these processes seems to be insignificant. The leading mechanism of liver mass recovery after subtotal resection is proliferation of hepatocytes.
引用
收藏
页码：155 / 161
页数：7
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