Increased circulating CRTH2(+)Tregs are associated with asthma control and exacerbation

被引：11

作者：

Chantveerawong, Teerapol ^{[1
]}

Sangkangjanavanich, Sasipa ^{[1
,2
]}

Chiewchalermsri, Chirawat ^{[1
,3
]}

Pradubpongsa, Panitan ^{[1
]}

Mitthamsiri, Wat ^{[1
]}

Jindarat, Sarawut ^{[4
]}

Wang, Ming ^{[5
,6
]}

Akdis, Mubeccel ^{[7
,8
]}

Sokolowska, Milena ^{[7
,8
]}

Akdis, Cezmi A. ^{[7
,8
]}

Sangasapaviliya, Atik ^{[1
]}

Boonpiyathad, Tadech ^{[1
,7
,8
]}

机构：

[1] Phramongkutklao Hosp, Dept Med, Div Allergy & Clin Immunol, Bangkok, Thailand

[2] Mahidol Univ, Fac Med, Dept Med, Div Allergy Immunol & Rheumatol,Ramathibodi Hosp, Bangkok, Thailand

[3] Srinakharinwirot Univ, Panyananthaphikkhu Chonprathan Med Ctr, Dept Med, Nonthaburi, Thailand

[4] Phramongkutklao Coll Med, Dept Pharmacol, Bangkok, Thailand

[5] Capital Med Univ, Beijing TongRen Hosp, Dept Otolaryngol Head & Neck Surg, Beijing, Peoples R China

[6] Beijing Inst Otolaryngol, Beijing Key Lab Nasal Dis, Beijing, Peoples R China

[7] Univ Zurich, Swiss Inst Allergy & Asthma Res SIAF, Davos, Switzerland

[8] Christine Kuhne Ctr Allergy Res & Educ CK CARE, Davos, Switzerland

来源：

ALLERGY | 2022年 / 77卷 / 02期

关键词：

ALI culture; allergic; asthma; asthma control test score; asthma exacerbation; CRTH2; epithelial tight junction; PGD2; Treg cells; Tregs dysfunction;

D O I：

10.1111/all.15145

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

The frequency of CRTH2(+)Tregs in patients with asthma, especially allergic phenotype is higher compared to healthy controls and shows a negative correlation with ACT scores and PEFR. CRTH2(+)Tregs increase during exacerbation and decrease after asthma control. In vitro investigations demonstrate that Tregs of allergic patients with asthma display Th2-biased character. Abbreviation: CRTH2, chemoattractant receptor-homologous molecule expressed on Th2 cells; Tregs, regulatory T cells; ACT, asthma control test; PEFR, peak expiratory flow rate.

引用

页码：681 / 685

页数：5

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