Increased circulating CRTH2(+)Tregs are associated with asthma control and exacerbation

被引：11
|
作者：
Chantveerawong, Teerapol [1 ]
Sangkangjanavanich, Sasipa [1 ,2 ]
Chiewchalermsri, Chirawat [1 ,3 ]
Pradubpongsa, Panitan [1 ]
Mitthamsiri, Wat [1 ]
Jindarat, Sarawut [4 ]
Wang, Ming [5 ,6 ]
Akdis, Mubeccel [7 ,8 ]
Sokolowska, Milena [7 ,8 ]
Akdis, Cezmi A. [7 ,8 ]
Sangasapaviliya, Atik [1 ]
Boonpiyathad, Tadech [1 ,7 ,8 ]
机构：
[1] Phramongkutklao Hosp, Dept Med, Div Allergy & Clin Immunol, Bangkok, Thailand
[2] Mahidol Univ, Fac Med, Dept Med, Div Allergy Immunol & Rheumatol,Ramathibodi Hosp, Bangkok, Thailand
[3] Srinakharinwirot Univ, Panyananthaphikkhu Chonprathan Med Ctr, Dept Med, Nonthaburi, Thailand
[4] Phramongkutklao Coll Med, Dept Pharmacol, Bangkok, Thailand
[5] Capital Med Univ, Beijing TongRen Hosp, Dept Otolaryngol Head & Neck Surg, Beijing, Peoples R China
[6] Beijing Inst Otolaryngol, Beijing Key Lab Nasal Dis, Beijing, Peoples R China
[7] Univ Zurich, Swiss Inst Allergy & Asthma Res SIAF, Davos, Switzerland
[8] Christine Kuhne Ctr Allergy Res & Educ CK CARE, Davos, Switzerland
来源：
ALLERGY | 2022年 / 77卷 / 02期
关键词：
ALI culture; allergic; asthma; asthma control test score; asthma exacerbation; CRTH2; epithelial tight junction; PGD2; Treg cells; Tregs dysfunction;
D O I：
10.1111/all.15145
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
The frequency of CRTH2(+)Tregs in patients with asthma, especially allergic phenotype is higher compared to healthy controls and shows a negative correlation with ACT scores and PEFR. CRTH2(+)Tregs increase during exacerbation and decrease after asthma control. In vitro investigations demonstrate that Tregs of allergic patients with asthma display Th2-biased character. Abbreviation: CRTH2, chemoattractant receptor-homologous molecule expressed on Th2 cells; Tregs, regulatory T cells; ACT, asthma control test; PEFR, peak expiratory flow rate.
引用
收藏
页码：681 / 685
页数：5
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