The effect of the association between CETP variant type and alcohol consumption on cholesterol level differs according to the ALDH2 variant type

被引:1
|
作者
Yoo, Min-Gyu [1 ]
Yun, Ji Ho [1 ]
Koo, Soo Kyung [1 ]
Lee, Hye-Ja [1 ]
机构
[1] Korea Dis Control & Prevent Agcy, Korea Natl Inst Hlth, Div Endocrine & Kidney Dis Res, Dept Chron Dis Convergence Res, 187 Osongsaengmyeong 2 Ro, Cheongju 28159, Chungcheongbuk, South Korea
关键词
ESTER TRANSFER PROTEIN; HIGH-DENSITY-LIPOPROTEIN; HDL CHOLESTEROL; CARDIOVASCULAR RISK; LIPID-LEVELS; GENE; POLYMORPHISM; GENOTYPES; MASS;
D O I
10.1038/s41598-022-19171-y
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Alcohol consumption is associated with a high increased lipid profile and this association may depend on genetic risk factors. In this study, we aimed to assess the effects of genetic variation associated with alcohol consumption on lipid profiles using data from two Korean population studies. We performed a genotype association study using the HEXA (n = 51,349) and KNHANES (n = 9158) data. Genotype analyses of the two sets of Korean population data showed associations of increased total cholesterol and high-density lipoprotein (HDL)-cholesterol with CETP rs708272. The HEXA and KNHANES populations revealed differences in HDL cholesterol according to the presence of CETP rs708272, independent of ALDH2 rs671 and alcohol consumption. In contrast, total cholesterol levels were associated with alcohol consumption and ALDH2 rs671 in men with CETP rs708272 (CT and TT genotypes). Furthermore, in drinkers with ALDH2 rs671 (GA and AA genotypes), higher total cholesterol was associated with the CETP rs708272 TT minor homozygous genotype based on both HEXA and KNHANES data. Our findings demonstrated that alcohol consumption and genetic variation in either CETP or ALDH2 may be associated with cholesterol levels. We hope these findings will provide a better understanding of the relationship between alcohol consumption and cholesterol according to each individual's genetic background.
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页数:10
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