Efficient Synthesis of Key Intermediate Toward Liphagal Synthesis

被引：10

作者：

Deore, Vijaykumar ^{[1
]}

Lohar, Manoj Kumar ^{[1
]}

Mundada, Ramswaroop ^{[1
]}

Roychowdhury, Abhijit ^{[1
]}

Vishwakarma, Ram ^{[1
]}

Kumar, Sanjay ^{[1
]}

机构：

[1] Piramal Life Sci, Dept Med Chem, Bombay 400063, Maharashtra, India

来源：

SYNTHETIC COMMUNICATIONS | 2011年 / 41卷 / 02期

关键词：

Anticancer; isoform selective inhibitor; liphagal; natural product synthesis; PI3K; PHOSPHOINOSITIDE 3-KINASE INHIBITORS; PATHWAY; P110-ALPHA;

D O I：

10.1080/00397910903531920

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Liphagal (A) is a very potent and selective inhibitor of PI3K (p110) and is under development for an oncolytic drug. We herein report the new and concise synthesis of key intermediates (7, 8), which have been used for liphagal synthesis and will be useful for generating liphagal-based chemical entities for drug discovery purposes.

引用

页码：177 / 183

页数：7

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