Multiple endocrine neoplasia-1 (MEN-1) is characterized by multiple endocrine tumors including parathyroid, islets of Langerhans, pituitary, and adrenal tumors. Most of these patients present with primary hyperparathyroidism. The adrenal tumors in MEN-1 are rare and usually bilateral and nonfunctional. To the best of our knowledge, this is the first report of primary hyperaldosteronism due to an adenoma as the presenting manifestation of MEN-1.