SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF SOME NOVEL 2-SUBSTITUTED MERCAPTOBENZIMIDAZOLE DERIVATIVES.

被引：0

作者：

Reddy, Malladi Srinivas ^{[1
]}

Anisetti, Ravinder Nath ^{[1
]}

Prasad, K. Durga ^{[2
]}

Sannigrahi, Santanu ^{[3
]}

Reddy, P. Arvinda ^{[4
]}

机构：

[1] Osmania Univ, Univ Coll Technol, Hyderabad 500007, Andhra Pradesh, India

[2] Natco Res Ctr, Lab 4, Hyderabad, Andhra Pradesh, India

[3] Jadavpur Univ, Dept Pharmaceut Technol, Kolkata 700032, W Bengal, India

[4] CL Baid Metha Coll Pharm, Dept Pharmaceut Chem, Madras 600096, Tamil Nadu, India

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2011年 / 44卷 / 11期

关键词：

2-mercapto benzimidazole; acid chlorides; anti-ulcer; anti-microbial; HELICOBACTER-PYLORI AGENTS; BENZIMIDAZOLE DERIVATIVES;

D O I：

10.1007/s11094-011-0537-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Synthesis and biological assessment of six novel 2-substituted mercaptobenzimidazole derivatives is performed. The title compounds are characterized by their analytical and spectral data. All the synthesized compounds are screened for their anti-ulcer and anti-microbial activity. 2-(1H-benzimidazole-2-sulfinyl) -N-(4-benzyloxy-phenyl)-acetamide, N-(4-benzyloxy-phenyl)-4-(1H-benzimidazole-2-sulfinyl)-butyramide, N-(4-benzyloxy phenyl)-4-(5-methoxy 1H-benzimidazole-2-sulfinyl)-butyramide showed significant antiulcer activity. All the compounds moderate antibacterial and antifungal activity.

引用

页码：642 / 645

页数：4

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