The transmural activation sequence in porcine and canine left ventricle is markedly different during long-duration ventricular fibrillation

被引:48
|
作者
Allison, J. Scott
Qin, Hao
Dosdall, Derek J.
Huang, Jian
Newton, Jonathan C.
Allred, James D.
Smith, William M.
Ideker, Raymond E.
机构
[1] Univ Alabama Birmingham, Dept Med, Div Cardiovasc Dis, Birmingham, AL 35294 USA
[2] Univ Alabama Birmingham, Dept Biomed Engn, Birmingham, AL 35294 USA
[3] Univ Alabama Birmingham, Dept Anesthesiol, Birmingham, AL 35294 USA
关键词
cardiac electrophysiology; arrhythmia; mapping; ventricles; fibrillation;
D O I
10.1111/j.1540-8167.2007.00963.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Transmural Activation Sequence in Ventricular Fibrillation. Background: Humans are more similar in transmural Purkinje and cardiac ion channel distributions to dogs than pigs. The Purkinje network in pigs is transmural but confined to the endocardium in dogs. Little is known about intramural activation during long-duration ventricular fibrillation (LDVF) given these differences. We tested the hypothesis that the transmural activation sequence is similar in sinus rhythm (SR) and LDVF in dogs as well as pigs, but different between species. Methods and Results: In six pigs and seven dogs, 50-60 plunge needles (six electrodes, 2-mm spacing) were placed throughout the left ventricle. Unipolar recordings were made for >10 minutes of LDVF. SR and LDVF activation times were grouped into waves by linking activations along each needle. Origin (earliest activation) and propagation direction were determined for each wave. The mean wave origin was significantly more endocardial in dogs than pigs for SR and 1 through 10 minutes of LDVF. Predominant propagation direction in LDVF and SR was endocardial to epicardial in dogs, but the opposite or equal in both directions in pigs. Fastest activation rate was epicardial in pigs, but endocardial in dogs with an increasing endocardial-to-epicardial activation rate gradient as LDVF progressed in dogs but not pigs. Conclusions: The transmural activation sequence in SR and LDVF is markedly different between pigs and dogs. These differences may be related to differences in Purkinje fiber and ion channel distributions and suggest that dogs are a better model for investigating activation sequences during LDVF, given the similarities with humans.
引用
收藏
页码:1306 / 1312
页数:7
相关论文
共 30 条
  • [21] Chemical ablation of the Purkinje system causes early termination and activation rate slowing of long-duration ventricular fibrillation in dogs
    Dosdall, Derek J.
    Tabereaux, Paul B.
    Kim, Jong J.
    Walcott, Gregory P.
    Rogers, Jack M.
    Killingsworth, Cheryl R.
    Huang, Jian
    Robertson, Peter G.
    Smith, William M.
    Ideker, Raymond E.
    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2008, 295 (02): : H883 - H889
  • [22] Transmural recording of shock potential gradient fields, early postshock activations, and refibrillation episodes associated with external defibrillation of long-duration ventricular fibrillation in swine
    Allred, James D.
    Killingsworth, Cheryl R.
    Allison, J. Scott
    Dosdall, Derek J.
    Melnick, Sharon B.
    Smith, William M.
    Ideker, Raymond E.
    Walcott, Gregory P.
    HEART RHYTHM, 2008, 5 (11) : 1599 - 1606
  • [23] PRESSURE-VOLUME RELATIONS AND OXYGEN CONSUMPTION IN THE ISOLATED CANINE LEFT VENTRICLE DURING POTASSIUM ARREST AND VENTRICULAR FIBRILLATION
    MONROE, G
    FRENCH, G
    FEDERATION PROCEEDINGS, 1959, 18 (01) : 107 - 107
  • [24] Increased cycle Length during long-duration ventricular fibrillation is caused by decreased upstroke velocity as well as prolonged refractoriness
    Robertson, Peter G.
    Huang, Jian
    Chen, Kang A.
    Chen, Xiaozhong
    Dosdall, Derek J.
    Tabereaux, Pau B.
    Smith, Wilham M.
    Ideker, Raymond E.
    HEART RHYTHM, 2009, 6 (03) : 378 - 384
  • [25] Transmural temporospatial left ventricular activation during pacing from different sites: potential implications for optimal pacing
    Kavanagh, Katherine M.
    Belenkie, Israel
    Duff, Henry J.
    CARDIOVASCULAR RESEARCH, 2008, 77 (01) : 81 - 88
  • [26] Evidence for ATP-Sensitive Potassium Current-Mediated Polymorphism in the Dynamics of Long-Duration Ventricular Fibrillation and Asystole in Isolated Canine Heart
    Taylor, Tyson G.
    Venable, Paul W.
    Warren, Mark
    Shibayama, Junko
    Zaitsev, Alexey V.
    CIRCULATION, 2010, 122 (21)
  • [27] Global Bi-ventricular endocardial distribution of activation rate during long duration ventricular fibrillation in normal and heart failure canines
    Luo, Qingzhi
    Jin, Qi
    Zhang, Ning
    Han, Yanxin
    Wang, Yilong
    Huang, Shangwei
    Lin, Changjian
    Ling, Tianyou
    Chen, Kang
    Pan, Wenqi
    Wu, Liqun
    BMC CARDIOVASCULAR DISORDERS, 2017, 17
  • [28] Global Bi-ventricular endocardial distribution of activation rate during long duration ventricular fibrillation in normal and heart failure canines
    Qingzhi Luo
    Qi Jin
    Ning Zhang
    Yanxin Han
    Yilong Wang
    Shangwei Huang
    Changjian Lin
    Tianyou Ling
    Kang Chen
    Wenqi Pan
    Liqun Wu
    BMC Cardiovascular Disorders, 17
  • [29] EPICARDIAL ACTIVATION PATTERNS AND DISPERSION OF REFRACTORINESS INITIATING VENTRICULAR-TACHYCARDIA IN THE CANINE LEFT-VENTRICLE DURING ACUTE-ISCHEMIA
    ISOMURA, S
    TOYAMA, J
    KODAMA, I
    YAMADA, K
    JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION, 1983, 47 (03): : 342 - 350
  • [30] Periods of Highly Organized Mon-Reentrant Endocardial Activation Can Occur During Long Duration Ventricular Fibrillation
    Robichaux, Robert P., Jr.
    Dosdall, Derek
    Osorio, Jose
    Garner, Nick
    Li, Li
    Ideker, Raymond E.
    CIRCULATION, 2008, 118 (18) : S1476 - S1476