ACTRIIA-Fc Rebalances BMP and Activin/TGF-β Signaling to Attenuate Experimental Pulmonary Hypertension

被引：0
|
作者：
Yung, L. [1 ]
Yang, P. [1 ]
Bocobo, G. [1 ]
Dinter, T. [1 ]
Pearsall, S. [2 ]
Sako, D. [2 ]
Kumar, R. [2 ]
Yu, P. B. [1 ]
机构：
[1] Harvard Med Sch, Brigham & Womens Hosp, Boston, MA USA
[2] Acceleron Pharma, Cambridge, MA USA
来源：
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE | 2018年 / 197卷
关键词：
D O I：
暂无
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
A7399
引用
收藏
页数：2
相关论文
共 50 条
  • [31] Inactivated Pseudomonas aeruginosa inhibits hypoxia-induced pulmonary hypertension by preventing TGF-β1/Smad signaling
    Chai, S. D.
    Liu, T.
    Dong, M. F.
    Li, Z. K.
    Tang, P. Z.
    Wang, J. T.
    Ma, S. J.
    BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, 2016, 49 (10)
  • [32] BMP-7 attenuated silica-induced pulmonary fibrosis through modulation of the balance between TGF-β/Smad and BMP-7/Smad signaling pathway
    Liang, Di
    Wang, Yan
    Zhu, Zhonghui
    Yang, Gengxia
    An, Guoliang
    Li, Xiaoli
    Niu, Piye
    Chen, Li
    Tian, Lin
    CHEMICO-BIOLOGICAL INTERACTIONS, 2016, 243 : 72 - 81
  • [33] MiR-21 regulates pulmonary hypertension in rats via TGF-β1/Smad2 signaling pathway
    Ding, F.
    You, T.
    Hou, X. -D.
    Yi, K.
    Liu, X. -G.
    Zhang, P.
    Wang, X. -K.
    EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 2020, 24 (17) : 8625 - 8625
  • [34] The role of TGF-β or BMPR2 signaling pathway-related miRNA in pulmonary arterial hypertension and systemic sclerosis
    Bei Xu
    Guanhua Xu
    Ye Yu
    Jin Lin
    Arthritis Research & Therapy, 23
  • [35] Consequences of Alteration in TGF-β/ALK1/endoglin Signaling in the Pathogenesis of Human and Rodent Pulmonary Arterial Hypertension.
    Gore, B.
    Dewachter, L.
    Tu, L.
    Fadel, E.
    Humbert, M.
    Lebrin, F.
    Guignabert, C.
    Eddahibi, S.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2010, 181
  • [36] Halofuginone prevents inflammation and proliferation of high-altitude pulmonary hypertension by inhibiting the TGF-β1/Smad signaling pathway
    Wang, Jiangtao
    Guan, Lina
    Yu, Jian
    Ma, Bohua
    Shen, Huihua
    Xing, Guozhu
    Xu, Yawei
    Li, Qiufang
    Liu, Juan
    Xu, Qin
    Shi, Wenhui
    He, Jia
    Huang, Yixuan
    Yin, Dongfeng
    Li, Wu
    Wang, Rui
    SCIENTIFIC REPORTS, 2025, 15 (01):
  • [37] The role of TGF-β or BMPR2 signaling pathway-related miRNA in pulmonary arterial hypertension and systemic sclerosis
    Xu, Bei
    Xu, Guanhua
    Yu, Ye
    Lin, Jin
    ARTHRITIS RESEARCH & THERAPY, 2021, 23 (01)
  • [38] Transcriptional Repression of the Transforming Growth Factor β (TGF-β) Pseudoreceptor BMP and Activin Membrane-bound Inhibitor (BAMBI) by Nuclear Factor κB (NF-κB) p50 Enhances TGF-β Signaling in Hepatic Stellate Cells
    Liu, Cheng
    Chen, Xiaorong
    Yang, Ling
    Kisseleva, Tatiana
    Brenner, David A.
    Seki, Ekihiro
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2014, 289 (10) : 7082 - 7091
  • [39] Nagilactone D ameliorates experimental pulmonary fibrosis in vitro and in vivo via modulating TGF-β/Smad signaling pathway
    Li, Ao
    Xiao, Xiao
    Feng, Zhe-Ling
    Chen, Xiuping
    Liu, Li-Juan
    Lin, Li-Gen
    Lu, Jin-Jian
    Zhang, Le-Le
    TOXICOLOGY AND APPLIED PHARMACOLOGY, 2020, 389
  • [40] Microvascular Endothelial Cells Of Pulmonary Arterial Hypertension Patients Are More Sensitive To Bmp9 Stimulation And Activate Both The Bmp And Tgf-Beta Signaling Cascade
    Rol, N.
    Szulcek, R.
    Kurakula, K.
    Pan, X.
    Dickhoff, C.
    Vonk-Noordegraaf, A.
    Goumans, M. T. H.
    Bogaard, H. J.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2017, 195
12345