Evaluation of shikonin on granulation tissue formation compared with carrageenan

被引：0
|
作者：
Sekine, T
Kojima, K
Matsumoto, T
Yamamoto, T
Maitani, Y
Nagai, T
机构：
[1] Tsumura & Co, Dept Pharmaceut Technol, Ami, Ibaraki 3001192, Japan
[2] Tsumura & Co, Dept Cent Res Labs, Ami, Ibaraki 3001192, Japan
[3] Hoshi Univ, Dept Pharmaceut, Shinagawa Ku, Tokyo 1428501, Japan
来源：
BIOLOGICAL & PHARMACEUTICAL BULLETIN | 1998年 / 21卷 / 09期
关键词：
shikonin; granulation tissue; cotton pellet; edema; carrageenan;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effect of shikonin (SK) on granulation tissue formation was biochemically evaluated and the biological effect of SK on cotton pellet induced granulation tissue formation and the induction of hind paw edema was compared with that of lambda-carrageenan (carrageenan) in rats. The dry weight of granulation tissue formed was increased by SK, The amounts of hemoglobin and hydroxyproline in granulation tissue were also increased by SK, These results suggest that SK has an enhancing effect on the formation of granulation tissue, accompanied by the proliferation of capillaries and the increased production of collagen in rats. SK showed mild stimulation toward swelling when injected into the hind paws of rats, as did carrageenan, while it showed a marked enhancing effect on granulation tissue formation compared with carrageenan, These results suggest that the mechanism underlying the biological effect of SK on granulation tissue formation is different from that of carrageenan, though the mild stimulation by SIC might still contribute in part to the enhancing effect on granulation tissue formation.
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页码：950 / 952
页数：3
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