Synthesis and biological activities of camphor-based non-peptide growth hormone secretagogues

被引：20

作者：

Nargund, RP ^{[1
]}

Barakat, KH ^{[1
]}

Cheng, K ^{[1
]}

Chan, WWS ^{[1
]}

Butler, BR ^{[1
]}

Smith, RG ^{[1
]}

Patchett, AA ^{[1
]}

机构：

[1] MERCK & CO INC,MERCK SHARP & DOHME RES LABS,DEPT PHYSIOL,RAHWAY,NJ 07065

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 11期

关键词：

D O I：

10.1016/0960-894X(96)00213-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and growth hormone (GH) releasing activities of a novel series of camphor-based non-peptide GH secretagogues is presented. Use of the (R)-nipecotic acid amino side-chain and N-terminal derivatization of it with an (R)-(2-hydroxy)propyl group provided a potent secretagogue 18 (EC(50) = 90 nM). An o-tolyl piperazine was identified as a good replacement for the spiroindanyl piperidine. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：1265 / 1270

页数：6

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