The safety of low platelet thresholds for prophylactic transfusions was retrospectively evaluated in 673 children with various thrombocytopenic disorders. In patients with idiopathic thrombocytopenic purpura and X linked thrombocytopenia the threshold for the use of platelet transfusion was based on bleeding events rather than platelet count. In children with hypoproliferative thrombocytopenia and Wiskott - Aldrich syndrome, prophylactic platelet transfusions were used when the platelet count was <= 5000/ mu l in stable patients and > 10,000/ mu l in cases of bleeding or infections. The restrictive policy of platelet transfusions was shown to be proved safe in many thrombocytopenic disorders.
机构:
Royal Vet Coll, Dept Vet Clin Sci, Equine Referral Hosp, N Mymms, Herts, EnglandRoyal Vet Coll, Dept Vet Clin Sci, Equine Referral Hosp, N Mymms, Herts, England
机构:
UT Southwestern Med Ctr, Dept Pathol, Div Transfus Med & Hemostasis, Dallas, TX USAUT Southwestern Med Ctr, Dept Pathol, Div Transfus Med & Hemostasis, Dallas, TX USA
Reddy, Manasa
Vuppala, Suchith
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Univ Texas Southwestern, Med Sch, Dallas, TX USAUT Southwestern Med Ctr, Dept Pathol, Div Transfus Med & Hemostasis, Dallas, TX USA
Vuppala, Suchith
Haque, Waqas
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Univ Texas Southwestern, Med Sch, Dallas, TX USAUT Southwestern Med Ctr, Dept Pathol, Div Transfus Med & Hemostasis, Dallas, TX USA
Haque, Waqas
Sarode, Ravi
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UT Southwestern Med Ctr, Dept Pathol, Div Transfus Med & Hemostasis, Dallas, TX USAUT Southwestern Med Ctr, Dept Pathol, Div Transfus Med & Hemostasis, Dallas, TX USA