Effects of bovine serum albumin (BSA) on the excited-state properties of meso-tetrakis(sulfonatophenyl) porphyrin (TPPS4)

被引：14
|
作者：
Goncalves, Pablo J. [1 ,2 ]
Bezerra, Fabio C. [1 ]
Almeida, Luciane M. [3 ]
Alonso, Lais [1 ]
Souza, Guilherme R. L. [4 ]
Alonso, Antonio [1 ]
Zilio, Sergio C. [1 ,5 ]
Borissevitch, Iouri E. [1 ,6 ]
机构：
[1] Univ Fed Goias, Inst Fis, BR-74001970 Goiania, Go, Brazil
[2] Univ Fed Goias, Inst Quim, BR-74001970 Goiania, Go, Brazil
[3] Univ Estadual Goias, Campus Henrique Santillo, BR-75132400 Anapolis, Go, Brazil
[4] Univ Fed Goias, Inst Ciencias Biol, BR-74001970 Goiania, Go, Brazil
[5] Univ Sao Paulo, Inst Fis Sao Carlos, Caixa Postal 369, BR-13560970 Sao Carlos, SP, Brazil
[6] Univ Sao Paulo, FFLCRP, Dept Fis, Av Bandeirantes 3900, BR-14040901 Ribeirao Preto, SP, Brazil
来源：
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS | 2019年 / 48卷 / 08期
关键词：
TSPP4; porphyrin; Interaction with albumin; Porphyrin photophysical characteristics; Z-scan; WATER-SOLUBLE PORPHYRINS; PHOTODYNAMIC THERAPY; FLUORESCENCE; PHTHALOCYANINES; PROTONATION; ABSORPTION; PROTEINS; AGENTS; CELLS; DYE;
D O I：
10.1007/s00249-019-01397-w
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
To infer changes in the photophysical properties of porphyrins due to complexation with albumin, a combination of Z-scan and conventional spectroscopic techniques was employed. We measured the characteristics of excited states of meso-tetrakis(sulfonatophenyl) porphyrin bound to bovine serum albumin and observed that the binding reduces the intersystem crossing quantum yield and increases the internal conversion one. A reverse saturable absorption process was observed in the nanosecond timescale. These results are important for prediction of the efficiency of this complex in medical and optical applications, because associating porphyrins to proteins enables better accumulation in tumors and improves its stability in optical devices, but at the same time, decreases its triplet quantum yield.
引用
收藏
页码：721 / 729
页数：9
相关论文
共 50 条
  • [41] Kinetics, mechanism and thermodynamics involved in sorption of meso-tetrakis(4-sulfonatophenyl) porphyrin onto chitosan in aqueous medium
    Saha, Tapan K.
    Karmaker, Subarna
    Alam, Md F.
    [J]. JOURNAL OF PORPHYRINS AND PHTHALOCYANINES, 2014, 18 (03) : 240 - 250
  • [42] Optical properties of oxotitanium (IV) meso-tetrakis(4-sulfonatophenyl)porphyrin intercalated into the layered double hydroxides (LDH) studied by laser spectroscopy
    Ryu, SY
    Yoon, M
    Choy, JH
    Hwang, SH
    Frube, A
    Asahi, T
    Masuhara, H
    [J]. BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 2003, 24 (04) : 446 - 452
  • [43] Photoinduced electron transfer reactions between meso-tetrakis(4-sulfonatophenyl)porphyrin and colloidal metal-semiconductor nanoparticles
    Kathiravan, A.
    Sathishkumar, Panneerselvam
    Renganathan, R.
    Anandan, S.
    [J]. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2009, 333 (1-3) : 175 - 181
  • [44] Aggregation kinetics of meso-tetrakis(4-sulfonatophenyl) porphine in the presence of proteins:: Temperature and ionic strength effects
    Andrade, SM
    Costa, SMB
    [J]. JOURNAL OF FLUORESCENCE, 2002, 12 (01) : 77 - 82
  • [45] Aggregation Kinetics of Meso-tetrakis(4-sulfonatophenyl) Porphine in the Presence of Proteins: Temperature and Ionic Strength Effects
    Suzana M. Andrade
    Silvia M. B. Costa
    [J]. Journal of Fluorescence, 2002, 12 : 77 - 82
  • [46] Interaction of meso-tetrakis (p-sulfonatophenyl) porphyrin (TSPP) with pyrimidines: A steady state and time-resolved fluorescence quenching study
    Kathiravan, A.
    Anbazhagan, V.
    Jhonsi, M. Asha
    Renganathan, R.
    [J]. JOURNAL OF MOLECULAR STRUCTURE, 2009, 919 (1-3) : 79 - 82
  • [47] Synthesis, Characterization and Properties of Iron(III) meso-Tetrakis(4-alkoxyphenyl) porphyrin Chloride
    Xu, Yong-Jun
    Gu, Zheng
    Zhao, Hong-Bin
    Wang, Li-Shen
    Ning, Man-Xia
    Qiu, Shi-Jun
    [J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE, 2008, 29 (10): : 1930 - 1936
  • [48] Studies on synthesis and properties of metallic complexes of meso-tetrakis (4-alkoxyphenyl) porphyrin (I)
    Zhao, Hong-Bin
    Cai, Jian
    Luo, Zhi-Qiang
    Ning, Jing-Heng
    Peng, Sheng-Ming
    Zhou, Jin-Hua
    [J]. Xiangtan Daxue Ziran Kexue Xuebao, 2000, 22 (01):
  • [49] The Interaction Between a New Water-Soluble Meso-Tetrakis (Carboxyl) Zinc(II) Porphyrin and Human Serum Albumin
    Jiang Yi-yu
    Wang Xiang-li
    Wang Hua-hua
    Zhang Lei
    Wang Hui
    Ji Liang-nian
    Liu Hai-yang
    [J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2016, 36 (09) : 2894 - 2900
  • [50] Photodynamic activity study of palladium(II) meso-tetrakis(4-sulfonatophenyl)porphyrin sensitizer on cancer cell line A549
    Kolar, Petr
    Kolarova, Hana
    Tomankova, Katerina
    Mosinger, Jiri
    [J]. METAL IONS IN BIOLOGY AND MEDICINE, VOL 10, 2008, 10 : 500 - +
12345