Ustekinumab for the treatment of psoriatic arthritis

被引：1
|
作者：
Chandler, David John [1 ]
Bewley, Anthony [2 ]
机构：
[1] Univ Oxford, Weatherall Inst Mol Med, Oxford OX3 9DS, England
[2] Royal London Hosp, London E1 1BB, England
来源：
EXPERT REVIEW OF CLINICAL PHARMACOLOGY | 2014年 / 7卷 / 02期
关键词：
biologics; cutaneous immunology; IL-12; IL-23; psoriasis; psoriatic arthritis; ustekinumab; TO-SEVERE PSORIASIS; MONOCLONAL-ANTIBODY; DOUBLE-BLIND; RHEUMATOID-ARTHRITIS; CARDIOVASCULAR EVENTS; INCREASED EXPRESSION; FIBROBLAST FUNCTION; PLAQUE PSORIASIS; TNF INHIBITION; GROWTH-FACTOR;
D O I：
10.1586/17512433.2014.888310
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Psoriatic arthritis occurs commonly in those with psoriasis and is associated with progressive joint destruction, physical disability, reduced quality of life and increased mortality. For many patients the currently available treatment options including the anti-TNF treatments are inadequate. Recent data suggest that ustekinumab can provide an effective treatment option in these patients. We discuss the role of ustekinumab in the treatment of psoriatic arthritis and highlight areas requiring further work.
引用
收藏
页码：111 / 121
页数：11
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