Versatile Synthesis of 4-Aryl Chroman and 1-Aryl Tetralins Through Metal-Free Reductive Arylations

被引：3
|
作者：
Panda, Gautam [1 ,2 ]
Kumar, Srinivas Lavanya M. [2 ]
机构：
[1] Acad Sci & Innovat Res, New Delhi 110001, India
[2] CSIR Cent Drug Res Inst, BS 10-1,Sect 10,Sitapur Rd, Lucknow 226031, Uttar Pradesh, India
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 2019卷 / 04期
关键词：
Chromans; Tetralins; Metal free coupling; Hydrazones; Reductive arylation; ORTHO-QUINONE METHIDES; TOSYLHYDRAZONES; TRANSITION; ALKENES; AGENTS; ACIDS; ALKYLATION; BARK;
D O I：
10.1002/ejoc.201801375
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A metal free approach was developed for accessing 4-aryl chromans and 1-aryl tetralins from their commercially available building blocks. This operationally simple protocol was well tolerated with the presence of labile functional groups, providing biologically relevant chemical libraries, which can be used for late stage modification. Dearylated analogues of the drugs Ormeloxifene and Lasofoxifene were synthesized using this approach.
引用
收藏
页码：753 / 758
页数：6
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