The role of T cell receptor signaling thresholds in guiding T cell fate decisions

被引：34
|
作者：
Zikherman, Julie [1 ]
Au-Yeung, Byron [1 ]
机构：
[1] Univ Calif San Francisco, Div Rheumatol, Dept Med, Rosalind Russell & Ephraim P Engleman Arthrit Res, San Francisco, CA 94143 USA
来源：
CURRENT OPINION IN IMMUNOLOGY | 2015年 / 33卷
关键词：
TYROSINE PHOSPHORYLATION; NEGATIVE SELECTION; THYMIC SELECTION; ACTIVATION; EXPANSION; RESPONSES; IRF4; SELF; DIFFERENTIATION; METABOLISM;
D O I：
10.1016/j.coi.2015.01.012
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Canonical T cell receptor signal transduction has been extensively studied and dissected in cell lines and primary lymphocytes. However, a static depiction of this signaling cascade fails to capture the complex and dynamic process by which individual T cells discriminate TCR:peptide-MHC affinity, then integrate signals over time to drive discrete cellular behaviors such as thymic selection, proliferation, and cytokine production. Recent technological advances have made it possible to study complex lymphocyte behavior on a single cell level and are revealing how T cells interpret information about affinity and abundance of antigen in order to make life-and-death cell fate decisions individually and collectively.
引用
收藏
页码：43 / 48
页数：6
相关论文
共 50 条
  • [31] Hypercholesterolemia Enhances T Cell Receptor Signaling and Increases the Regulatory T Cell Population
    Mailer, Reiner K. W.
    Gistera, Anton
    Polyzos, Konstantinos A.
    Ketelhuth, Daniel F. J.
    Hansson, Goran K.
    SCIENTIFIC REPORTS, 2017, 7
  • [32] T-cell receptor signaling and growth pathways in T-cell tumors
    Admirand, JH
    Herling, M
    Patel, K
    Rassidakis, GZ
    Oyarzo, MP
    Medeiros, LJ
    Jones, D
    LABORATORY INVESTIGATION, 2005, 85 : 220A - 220A
  • [33] Fine-tuning T cell receptor signaling to control T cell development
    Fu, Guo
    Rybakin, Vasily
    Brzostek, Joanna
    Paster, Wolfgang
    Acuto, Oreste
    Gascoigne, Nicholas R. J.
    TRENDS IN IMMUNOLOGY, 2014, 35 (07) : 311 - 318
  • [34] Hypercholesterolemia Enhances T Cell Receptor Signaling and Increases the Regulatory T Cell Population
    Reiner K. W. Mailer
    Anton Gisterå
    Konstantinos A. Polyzos
    Daniel F. J. Ketelhuth
    Göran K. Hansson
    Scientific Reports, 7
  • [35] T-cell receptor signaling and growth pathways in T-cell tumors
    Admirand, JH
    Herling, M
    Patel, K
    Rassidakis, G
    Oyarzo, MP
    Medeiros, LJ
    Jones, D
    MODERN PATHOLOGY, 2005, 18 : 220A - 220A
  • [36] T-cell receptor signaling to integrins
    Burbach, Brandon J.
    Medeiros, Ricardo B.
    Mueller, Kristen L.
    Shimizu, Yoji
    IMMUNOLOGICAL REVIEWS, 2007, 218 : 65 - 81
  • [37] Dissecting T cell receptor nanocluster signaling
    Manz, Boryana N.
    Jackson, Bryan L.
    Petit, Rebecca S.
    Dustin, Michael L.
    Groves, Jay T.
    BIOPHYSICAL JOURNAL, 2009, 96 (03) : 680A - 681A
  • [38] T cell receptor signaling in rheumatoid arthritis
    Verweij, CL
    ANNALS OF THE RHEUMATIC DISEASES, 2004, 63 : 16 - 16
  • [39] Glucocorticoids attenuate T cell receptor signaling
    Van Laethem, F
    Baus, E
    Smyth, LA
    Andris, F
    Bex, F
    Urbain, J
    Kioussis, D
    Leo, O
    JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 193 (07): : 803 - 814
  • [40] In vitro reconstitution of T cell receptor signaling
    Hui, E.
    Vale, R.
    MOLECULAR BIOLOGY OF THE CELL, 2012, 23
12345