This paper tackles the need for the elaboration of the theoretical basis and the development of practical recommendations for integrating the principles of a socially responsible concept into the strategic development of domestic enterprises. Achieving this task appears to be important in order to consolidate private and public priorities of increasing the competitiveness of Ukrainian business. Our paper is based on an own and original survey. The basis for the survey became the information obtained through the survey of 500 respondents of small, medium and large enterprises of the Odessa region by the method of personal interviews, talks and questionnaires in 2016. The obtained results of the study were analyzed on the basis of a systematic approach using the method of structuring, empirical research and statistical analysis, expert evaluations and comparison, generalization, analysis and synthesis. Our results demonstrate that a socially responsible strategy of the development of enterprises of the region of any production size should consider the harmonization of the socially-economic interests of the concerned parties in order to prevent the emergence of economic conflicts.