Catalyst and solvent-free amidation of inactive esters of N-protected amino acids

被引：20

作者：

Nadimpally, Krishna Chaitanya ^{[1
]}

Thalluri, Kishore ^{[1
]}

Palakurthy, Nani Babu ^{[1
]}

Saha, Abhijit ^{[1
]}

Mandal, Bhubaneswar ^{[1
]}

机构：

[1] Indian Inst Technol, Dept Chem, Gauhati 781039, Assam, India

来源：

TETRAHEDRON LETTERS | 2011年 / 52卷 / 20期

关键词：

Aminolysis; Inactive esters; Amino acid; Amidation; MICROWAVE IRRADIATION; PEPTIDE SYNTHESIS; L-PHENYLALANINE; ACTIVE ESTERS; AMIDES; AMMONOLYSIS; DERIVATIVES;

D O I：

10.1016/j.tetlet.2011.03.039

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A catalyst free procedure for the preparation of amides from inactive esters of N-protected amino acids and various amines is demonstrated under mild reaction conditions. Our effort to recover excess amine and generated alcohol is an approach towards environment friendly and cost effective synthesis under easy operational conditions. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：2579 / 2582

页数：4

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