Persistence of Yellow Fever vaccine-induced antibodies after cord blood stem cell transplant

被引：4

作者：

Avelino-Silva, Vivian Iida ^{[1
,2
]}

Freire, Marcos da Silva ^{[3
]}

Rocha, Vanderson ^{[2
]}

Rodrigues, Celso Arrais ^{[2
]}

Novis, Yana Sarkis ^{[2
]}

Sabino, Ester C. ^{[1
,4
]}

Kallas, Esper Georges ^{[1
,2
,5
]}

机构：

[1] Univ Sao Paulo, Sch Med, Dept Infect & Parasit Dis, Sao Paulo, Brazil

[2] Hosp Sirio Libanes, Sao Paulo, Brazil

[3] Fundacao Oswaldo Cruz, Rio De Janeiro, Brazil

[4] Fundacao Prosangue Hemoctr Sao Paulo, Sao Paulo, Brazil

[5] Univ Sao Paulo, Sch Med, Div Clin Immunol & Allergy, Sao Paulo, Brazil

来源：

HUMAN VACCINES & IMMUNOTHERAPEUTICS | 2016年 / 12卷 / 04期

关键词：

cord blood stem cell transplant; immunosuppression; vaccine; yellow fever; INFECTION; IMMUNITY; VIREMIA;

D O I：

10.1080/21645515.2015.1112475

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We report the case of a cord blood haematopoietic stem cell transplant recipient who was vaccinated for Yellow Fever (YF) 7days before initiating chemotherapy and had persistent YF antibodies more than 3years after vaccination. Since the stem cell donor was never exposed to wild YF or to the YF vaccine, and our patient was not exposed to YF or revaccinated, this finding strongly suggests the persistence of recipient immunity. We briefly discuss potential consequences of incomplete elimination of recipient's leukocytes following existing haematopoietic cancer treatments.

引用

页码：937 / 938

页数：2

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