Clinical Efficacy of Ruxolitinib in Patients with Myelofibrosis: A Nationwide Population-Based Study in Korea

被引:3
|
作者
Lee, Byung-Hyun [1 ]
Moon, Hyemi [2 ]
Chae, Jae-Eun [2 ]
Kang, Ka-Won [1 ]
Kim, Byung-Soo [1 ]
Lee, Juneyoung [2 ]
Park, Yong [1 ]
机构
[1] Korea Univ, Anam Hosp, Dept Internal Med, Coll Med, Seoul 02841, South Korea
[2] Korea Univ, Dept Biostat, Coll Med, Seoul 02841, South Korea
关键词
myelofibrosis; ruxolitinib; National Health Insurance; propensity score; prognosis; POST-ESSENTIAL THROMBOCYTHEMIA; AVAILABLE THERAPY; POLYCYTHEMIA-VERA; COMFORT-II; SURVIVAL; PHASE-3; SAFETY;
D O I
10.3390/jcm10204774
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Previous studies have reported the survival benefit after ruxolitinib treatment in patients with myelofibrosis (MF). However, population-based data of its efficacy are limited. We analyzed the effects of ruxolitinib in MF patients with data from the Korean National Health Insurance Database. In total, 1199 patients diagnosed with MF from January 2011 to December 2017 were identified, of which 731 were included in this study. Patients who received ruxolitinib (n = 224) were matched with those who did not receive the drug (n = 507) using the 1:1 greedy algorithm. Propensity scores were formulated using five variables: age, sex, previous history of arterial/venous thrombosis, and red blood cell (RBC) or platelet (PLT) transfusion dependence at the time of diagnosis. Cox regression analysis for overall survival (OS) revealed that ruxolitinib treatment (hazard ratio (HR), 0.67; p = 0.017) was significantly related to superior survival. In the multivariable analysis for OS, older age (HR, 1.07; p < 0.001), male sex (HR, 1.94; p = 0.021), and RBC (HR, 3.72; p < 0.001) or PLT (HR, 9.58; p = 0.001) transfusion dependence were significantly associated with poor survival, although type of MF did not significantly affect survival. Considering evidence supporting these results remains weak, further studies on the efficacy of ruxolitinib in other populations are needed.
引用
收藏
页数:10
相关论文
共 50 条
  • [31] Epidemiologic study of bladder and urethral injury in Korea: A nationwide population-based study
    Tae, Bum Sik
    Yoon, Young Eun
    Na, Woong
    Oh, Kyung Jin
    Park, Sung Yul
    Park, Jae Young
    Moon, Hong Sang
    [J]. INVESTIGATIVE AND CLINICAL UROLOGY, 2022, 63 (01) : 92 - 98
  • [32] Prevalence and Incidence of Developmental Disorders in Korea: A Nationwide Population-Based Study
    Sung Sil Rah
    Soon-Beom Hong
    Ju Young Yoon
    [J]. Journal of Autism and Developmental Disorders, 2020, 50 : 4504 - 4511
  • [33] Prevalence and Incidence of Developmental Disorders in Korea: A Nationwide Population-Based Study
    Rah, Sung Sil
    Hong, Soon-Beom
    Yoon, Ju Young
    [J]. JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS, 2020, 50 (12) : 4504 - 4511
  • [34] Ambient Temperature and Prevalence of Obesity: A Nationwide Population-Based Study in Korea
    Yang, Hae Kyung
    Han, Kyungdo
    Cho, Jae-Hyoung
    Yoon, Kun-Ho
    Cha, Bong-Yun
    Lee, Seung-Hwan
    [J]. PLOS ONE, 2015, 10 (11):
  • [35] Vitiligo and overt thyroid diseases: A nationwide population-based study in Korea
    Bae, Jung Min
    Lee, June Hyunkyung
    Yun, Jae Seung
    Han, Byeol
    Han, Tae Young
    [J]. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2017, 76 (05) : 871 - 878
  • [36] Association between vitiligo and smoking: A nationwide population-based study in Korea
    Young Bok Lee
    Ji Hyun Lee
    Soo Young Lee
    Dong Soo Yu
    Kyung Do Han
    Yong Gyu Park
    [J]. Scientific Reports, 10
  • [37] Prevalence and Incidence of Keratoconus in South Korea: A Nationwide Population-based Study
    Hwang, Sungsoon
    Lim, Dong Hui
    Chung, Tae-Young
    [J]. AMERICAN JOURNAL OF OPHTHALMOLOGY, 2018, 192 : 56 - 64
  • [38] A Nationwide Population-Based Study of Low Vision and Blindness in South Korea
    Park, Shin Hae
    Lee, Ji Sung
    Heo, Hwan
    Suh, Young-Woo
    Kim, Seung-Hyun
    Lim, Key Hwan
    Moon, Nam Ju
    Lee, Sung Jin
    Park, Song Hee
    Baek, Seung-Hee
    [J]. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2015, 56 (01) : 484 - 493
  • [39] Epidemiology and Management of Immune Thrombocytopenia: A Nationwide Population-Based Study in Korea
    Lee, Ji Yun
    Lee, Ju Hyun
    Lee, Jung-Ok
    Bang, Soo-Mee
    [J]. BLOOD, 2016, 128 (22)
  • [40] Association between vitiligo and smoking: A nationwide population-based study in Korea
    Lee, Young Bok
    Lee, Ji Hyun
    Lee, Soo Young
    Yu, Dong Soo
    Han, Kyung Do
    Park, Yong Gyu
    [J]. SCIENTIFIC REPORTS, 2020, 10 (01)