The influence of crosslinking amylose-methacrylic acid graft copolymers on the release of BSA

被引：1
|
作者：
Silva, Itziar [1 ]
Gurruchaga, Marilo [1 ]
Goni, Isabel [1 ]
机构：
[1] Univ Basque Country, Inst Polymer Mat, POLYMAt, Dept Polymer Sci & Technol, P Code 1072, San Sebastian 20080, Spain
来源：
MACROMOLECULAR SYMPOSIA | 2007年 / 253卷
关键词：
crosslinking; drug delivery systems; graft copolymers; proteins; starch;
D O I：
10.1002/masy.200750711
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
One of the biggest challenges in the drug delivery field is to obtain oral systems for the release of pepticles and proteins, enabling their use as therapeutic agents for clinical applications. The aim of this work is to obtain biodegradable copolymers suitable for the development of matrices which offer controlled release of proteins to be administered orally. Graft copolymers of amylose-methacrylic acid were synthesized using different amounts of the crosslinker N, N'-methylenediacrylamide. The influence on the release profiles of bovine serum albumin (BSA) was researched.
引用
收藏
页码：82 / 87
页数：6
相关论文
共 50 条
  • [21] STUDIES ON IONICALLY CROSSLINKED POLYSTYRENE .I. IONIC CROSSLINKING OF STYRENE-METHACRYLIC ACID COPOLYMERS IN EMULSION STATE
    IDE, F
    KODAMA, T
    HASEGAWA, A
    CHEMISTRY OF HIGH POLYMERS, 1969, 26 (296): : 863 - &
  • [22] Optimization of methacrylic acid ester copolymers blends as controlled release coatings using response surface methodology
    AlKhatib, HS
    Sakr, A
    PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, 2003, 8 (01) : 87 - 96
  • [23] Synthesis of graft copolymers of poly(methacrylic acid)-g-poly(ε-caprolactone) by coupling ROP and RAFT polymerizations
    Kiehl, J.
    Delaite, C.
    Bistac, S.
    Schuller, A. S.
    Farge, H.
    POLYMER, 2012, 53 (03) : 694 - 700
  • [24] GRAFT-COPOLYMERS OF METHACRYLIC-ACID AND SBS AND K-RESIN BY THE ANTHRACENE PHOTOSENSITIZED FORMATION OF HYDROPEROXIDES
    DONG, XX
    GEUSKENS, G
    WILKIE, CA
    EUROPEAN POLYMER JOURNAL, 1995, 31 (12) : 1165 - 1168
  • [25] Influence of methacrylic acid and hydroxypropylmethyl cellulose on the tablet properties and in vitro release of dextromethorphan hydrobromide
    Takka, S
    Bharaj, SS
    Sakr, A
    PHARMAZIE, 2003, 58 (12): : 886 - 890
  • [26] Tailoring Butyl Methacrylate/Methacrylic Acid Copolymers for the Solubilization of Membrane Proteins: The Influence of Composition and Molecular Weight
    Janata, Miroslav
    Cadova, Eva
    Angelisova, Pavla
    Charnavets, Tatsiana
    Horejsi, Vaclav
    Raus, Vladimir
    MACROMOLECULAR BIOSCIENCE, 2022, 22 (10)
  • [27] INFLUENCE OF HYDROGEN-BONDS NETWORK ON SORPTION CHARACTERISTICS OF METHYL METHACRYLATE-METHACRYLIC ACID COPOLYMERS
    KALYUZHN.LM
    PANOV, YN
    FRENKEL, SY
    VYSOKOMOLEKULYARNYE SOEDINENIYA SERIYA A, 1974, 16 (09): : 2036 - 2040
  • [28] Synthesis, Characterization, Drug Solubility Enhancement, and Drug Release Study of Poly(Methacrylic Acid-graft-Simvastatin)
    Alam, Bohaissa Mohamad
    Aouak, Taieb
    Alandis, Nasser Mohamed
    Alam, Mohammad Mezbaul
    INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS, 2015, 64 (05) : 229 - 241
  • [29] Control Release of Some Pesticides from Starch/(Ethylene glycol-co-methacrylic acid) Copolymers Prepared by γ-Irradiation
    Abd El-Mohdy, H. L.
    Hegazy, E. A.
    El-Nesr, E. M.
    El-Wahab, M. A.
    JOURNAL OF APPLIED POLYMER SCIENCE, 2011, 122 (03) : 1500 - 1509
  • [30] Control release of some pesticides from Starch/(Ethylene glycol-co-Methacrylic acid) copolymers prepared by γ-irradiation
    Abd El-Mohdy, H. L.
    Hegazy, E. A.
    El-Nesr, E. M.
    Abd El-Wahab, Mohamed
    JOURNAL OF POLYMER RESEARCH, 2011, 18 (06) : 1605 - 1615
12345