Antibiotic Resistance: The Need For a Global Strategy

被引:18
|
作者
Elder, David P. [1 ]
Kuentz, Martin [2 ]
Holm, Rene [3 ,4 ]
机构
[1] GlaxoSmithKline, Ware SG12 0DP, Herts, England
[2] Univ Appl Sci & Arts Northwestern Switzerland, Inst Pharmaceut Technol, CH-4132 Muttenz, Switzerland
[3] H Lundbeck & Co AS, Pharmaceut Sci, DK-2500 Valby, Denmark
[4] H Lundbeck & Co AS, CMC Biol, DK-2500 Valby, Denmark
关键词
antiinfectives; drug resistance; drug-like properties; formulation; global health; DRUG DISCOVERY; HEALTH; CHALLENGES; TRADE;
D O I
10.1016/j.xphs.2016.06.002
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
The development of antibiotic resistance is a major problem for mankind and results in fatal consequences on a daily basis across the globe. There are a number of reasons for this situation including increasing globalization with worldwide travel, health tourism, over use and ineffective use ( both in man and animals), and counterfeiting of the antimicrobial drug products we have available currently. Although there are huge economical, demographic, legal and logistic differences among the global communities, there are also differences regarding the best approach to dealing with antibiotic resistance. However, as resistant bacteria do not respect international borders, there is clearly a need for a global strategy to minimize the spread of antibiotic resistance, to optimize the use of antibiotics, and to facilitate the development of new and effective medications. This commentary provides an insight into the issues and some of the ongoing programs to ensure an effective treatment for the future. (C) 2016 Published by Elsevier Inc. on behalf of the American Pharmacists
引用
收藏
页码:2278 / 2287
页数:10
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