Health-related quality of life in transplant eligible multiple myeloma patients with or without early ASCT in the real-world setting

被引：6
|
作者：
Asrar, Mir M. [1 ]
Lad, Deepesh P. [2 ]
Bansal, Dipika [1 ]
Prinja, Shankar [3 ]
Khadwal, Alka [2 ]
Prakash, Gaurav [2 ]
Jain, Arihant [2 ]
Jandial, Aditya [2 ]
Malhotra, Pankaj [2 ]
机构：
[1] Natl Inst Pharmaceut Educ & Res NIPER, Clin Res Unit, Sas Nagar, India
[2] Postgrad Inst Med Educ & Res, Dept Internal Med, Chandigarh, India
[3] Postgrad Inst Med Educ & Res, Dept Community Med & Sch Publ Hlth, Chandigarh, India
来源：
LEUKEMIA & LYMPHOMA | 2021年 / 62卷 / 13期
关键词：
Multiple myeloma; early ASCT; HR-QoL; AUTOLOGOUS TRANSPLANTATION; CELL TRANSPLANTATION; INDUCTION;
D O I：
10.1080/10428194.2021.1953011
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
There is no comparative health-related quality of life (HR-QoL) data of transplant eligible (TE) multiple myeloma (MM) patients undergoing early autologous stem cell transplantation (ASCT) and those without in the era of novel drugs. This study prospectively evaluated the serial HR-QoL in TE-MM using the EORTC QLQ-C30 and MY20 questionnaires. Barring the transient worsening in QoL one-month after ASCT, there was a comparable improvement in most QoL domains in both early-ASCT and no-early ASCT cohorts. Post-early-ASCT patients had higher global health scores (71.9 vs. 60.8, p < .05) than no-early ASCT at 12-months. Patients belonging to lower socioeconomic status (SES) were more likely not to undergo ASCT than middle-high SES patients (38.6% vs. 74.5%, p < .05). While age, gender had no impact on QoL, performance status, staging, and induction therapy impacted QoL. This study shows that early ASCT maintains QoL and should be encouraged in all TE-MM patients.
引用
收藏
页码：3271 / 3277
页数：7
相关论文
共 50 条
  • [41] Health-related quality of life and use of medication with anticholinergic activity in patients with multiple myeloma
    de Lima, Mariana Sampaio Rodrigues
    de Padua, Cristiane Aparecida Menezes
    Drummond, Paula Lana de Miranda
    Silveira, Livia Pena
    Malta, Jessica Soares
    dos Santos, Roberta Marcia Marques
    Reis, Adriano Max Moreira
    SUPPORTIVE CARE IN CANCER, 2023, 31 (07)
  • [42] ASSOCIATION OF HEALTH-RELATED QUALITY OF LIFE AMONG PATIENTS WITH MULTIPLE MYELOMA WITH INSURANCE COVERAGE
    Pashos, C. L.
    Durie, B. G.
    Rifkin, R. M.
    Abonour, R.
    Fonseca, R.
    Gasparetto, C.
    Mehta, J.
    Narang, M.
    Shah, J. J.
    Terebelo, H. R.
    Thomas, S.
    Toomey, K.
    Swern, A. S.
    Harding, G.
    Yu, R.
    Sullivan, K. A.
    Street, T. K.
    Khan, Z. M.
    VALUE IN HEALTH, 2012, 15 (04) : A233 - A234
  • [43] HEALTH-RELATED QUALITY OF LIFE IN PATIENTS WITH MULTIPLE MYELOMA IN RELATION TO LINE OF TREATMENT AND RESPONSE
    Hu, X. H.
    Bozena, K.
    Lowe, M.
    Purnomo, L.
    Gibson, C.
    Rodriguez, A. M.
    HAEMATOLOGICA, 2016, 101 : 603 - 603
  • [44] Health-related quality of life and patients' perceptions in interferon-treated multiple myeloma patients
    Wisloff, F
    Gulbrandsen, N
    ACTA ONCOLOGICA, 2000, 39 (07) : 809 - 813
  • [45] Bortezomib therapy in a real-world setting in patients with relapsed or refractory multiple myeloma
    Huang, Shang-Yi
    Chen, Tsai-Yun
    Kuo, Ching-Yuan
    Chen, Yeu-Chin
    Lin, Sheng-Fung
    Chang, Ming-Chih
    Lv, Xinzhu
    Yang, Betty
    Chang, Cheng-Shyong
    ONCOLOGY REVIEWS, 2019, 13 (01) : 15 - 22
  • [46] Health-Related Quality of Life in Transplant-Eligible Patients with Newly Diagnosed Multiple Myeloma Treated with Daratumumab, Lenalidomide, Bortezomib, and Dexamethasone: Patient Reported Outcomes from GRIFFIN
    Silbermann, Rebecca
    Laubach, Jacob
    Kaufman, Jonathan L.
    Sborov, Douglas W.
    Reeves, Brandi
    Rodriguez, Cesar
    Chari, Ajai
    Costa, Luciano J.
    Anderson, Larry D.
    Nathwani, Nitya
    Shah, Nina
    Bumma, Naresh
    Holstein, Sarah A.
    Costello, Caitlin
    Jakubowiak, Andrzej
    Orlowski, Robert Z.
    Shain, Kenneth H.
    Cowan, Andrew J.
    Gries, Katharine S.
    Pei, Huiling
    Cortoos, Annelore
    Patel, Sharmila
    Lin, Thomas S.
    Richardson, Paul G.
    Usmani, Saad
    Voorhees, Peter M.
    BLOOD, 2022, 140 : 1146 - 1149
  • [47] Health-related quality of life in patients with early multiple sclerosis in the BEST study
    Cella, D
    Kappos, L
    Eremenco, S
    Kaskel, R
    Miltenburger, C
    JOURNAL OF NEUROLOGY, 2005, 252 : 40 - 40
  • [48] One-Year Interim Analysis of Health-Related Quality of Life in RRMS Patients Treated With Alemtuzumab in a Real-world Clinical Setting (LemQoL Study)
    Van Wijmeersch, B.
    Harrower, T.
    Hobart, J.
    Kizlaitiene, R.
    Marfia, G. A.
    Patti, F.
    Pearson, O. R.
    Van Pesch, V.
    Vanderdonckt, P.
    Vecsei, L.
    Shor, S.
    Achiron, A.
    EUROPEAN JOURNAL OF NEUROLOGY, 2020, 27 : 1144 - 1144
  • [49] WORLD HEALTH ORGANIZATION FUNCTIONAL CLASS AND HEALTH-RELATED QUALITY OF LIFE IN PATIENTS WITH PULMONARY ARTERIAL HYPERTENSION: REAL-WORLD FINDINGS IN LATIN AMERICA
    Pineda, Tatiana
    Bennett, Alex
    Bluro, Ignacio M.
    Harley, Julia
    Hernandez-Oropeza, Jose Luis J. L.
    Lescano, Adrian
    Meyer, Gisela M. B.
    Orozco-Levi, M.
    Pulido, Tomas
    Ramirez, Alicia
    Small, Mark P.
    Valencia, Angelo
    Souza, Rogerio
    CHEST, 2022, 162 (04) : 2323A - 2324A
  • [50] Health-related quality of life in patients with multiple sclerosis
    Malkova, NA
    Ryabukhina, OV
    Babenko, LA
    Ionova, TI
    Kishtovich, AV
    ZHURNAL NEVROLOGII I PSIKHIATRII IMENI S S KORSAKOVA, 2005, 105 (12) : 31 - 37
12345