1,3,4-Thiadiazoles: A potent multi targeted pharmacological scaffold

被引：151
|
作者：
Haider, Saqlain [1 ,2 ]
Alam, Mohammad Samar [2 ]
Hamid, Hinna [2 ]
机构：
[1] Univ Mississippi, Sch Pharm, Natl Ctr Nat Prod Res, University, MS 38677 USA
[2] Jamia Hamdard, Fac Sci, Dept Chem, New Delhi 110062, India
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2015年 / 92卷
关键词：
1,3,4-Thiadiazole; Mesoionic; Syndones; Anticancer; Anti-inflammatory; Hyperlipidaemia; CARBONIC-ANHYDRASE INHIBITORS; ANTI-HIV ACTIVITY; ANTICONVULSANT ACTIVITY; ANTIINFLAMMATORY ACTIVITIES; ANTIPROLIFERATIVE ACTIVITY; ANTIMICROBIAL ACTIVITY; ANTITUMOR-ACTIVITY; DERIVATIVES; ACETAZOLAMIDE; DESIGN;
D O I：
10.1016/j.ejmech.2014.12.035
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Despite a significant work on thiadiazoles, continuous efforts are still being made to identify novel heterocyclic compounds with potent biological activities. This review may help the medicinal chemists to develop new leads possessing 1,3,4-thiadiazole nucleus with higher efficacy and reduced side effects. This review throws light on the detailed synthetic approaches which have been used for the synthesis of thiadiazoles. This has been followed by the in depth analysis of the thiadiazoles with respect to their medicinal significance. (C) 2014 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：156 / 177
页数：22
相关论文
共 50 条
  • [41] MESOIONIC 2-ACYLIMINO-1,3,4-THIADIAZOLES
    LAZARIS, AY
    EGOROCHKIN, AN
    KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, 1975, (05): : 648 - 649
  • [42] REACTIVITY OF 2-AMINO-1,3,4-THIADIAZOLES - NUCLEOPHILIC BEHAVIOR OF SOME 2-AMINO-1,3,4-THIADIAZOLES - MODEL COMPOUNDS
    WERBER, G
    BUCCHERI, F
    GENTILE, M
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 1977, 14 (07) : 1263 - 1265
  • [43] Synthesis and bioassay of aminosulfonyl-1,3,4-oxadiazoles and their interconversion to 1,3,4-thiadiazoles
    Padmavathi, V.
    Reddy, S. Nagi
    Reddy, G. Dinneswara
    Padmaja, A.
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2010, 45 (09) : 4246 - 4251
  • [44] REACTIVITY OF 2-AMINO-1,3,4-THIADIAZOLES - METHYLATION REACTIONS OF SOME 2-AMINO-5-BENZOYL-1,3,4-THIADIAZOLES
    WERBER, G
    BUCCHERI, F
    VIVONA, N
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 1975, 12 (05) : 841 - 844
  • [45] Some substituted 1,3,4-thiadiazoles: a novel centrally acting agents
    Sharma, Rajesh
    Prasad, Yogendra
    Mishra, Ganesh Prasad
    Chaturvedi, S. C.
    MEDICINAL CHEMISTRY RESEARCH, 2014, 23 (01) : 252 - 258
  • [46] MESO-IONIC 1,3,4-THIADIAZOLES, REACTION WITH METHYL AZODICARBOXYLATE
    MOSBY, WL
    VEGA, ML
    JOURNAL OF THE CHEMICAL SOCIETY D-CHEMICAL COMMUNICATIONS, 1971, (15): : 837 - &
  • [47] Synthesis and antimicrobial activity of new pyrimidine incorporated 1,3,4-thiadiazoles
    Patil, LR
    Mandhare, PN
    Bondge, SP
    Munde, SB
    Mane, RA
    INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2003, 12 (03) : 245 - 248
  • [48] Electrochemical oxidative synthesis of 1,3,4-thiadiazoles from isothiocyanates and hydrazones
    Ma, Zhongxiao
    Hu, Xiao
    Li, Yanni
    Liang, Deqiang
    Dong, Ying
    Wang, Baoling
    Li, Weili
    ORGANIC CHEMISTRY FRONTIERS, 2021, 8 (10): : 2208 - 2214
  • [49] Synthesis of substituted 1,3,4-thiadiazoles using Lawesson's reagent
    Gierczyk, B
    Zalas, M
    ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL, 2005, 37 (03) : 213 - 222
  • [50] In silico characterization and preliminary anticancer assessment of some 1,3,4-thiadiazoles
    Vasile, Alina-Alexandra
    Stefaniu, Amalia
    Pintilie, Lucia
    Stanciu, Gabriela
    Ungureanu, Eleonora-Mihaela
    UPB Scientific Bulletin, Series B: Chemistry and Materials Science, 2021, 83 (03): : 3 - 12
12345