Ep-CAM overexpression in breast cancer as a predictor of survival

被引：245

作者：

Gastl, G ^{[1
]}

Spizzo, G

Obrist, P

Dünser, M

Mikuz, G

机构：

[1] Univ Innsbruck, Div Haematol & Oncol, A-6020 Innsbruck, Austria

[2] Univ Innsbruck, Inst Pathol, A-6020 Innsbruck, Austria

[3] Univ Innsbruck, Dept Surg, A-6020 Innsbruck, Austria

来源：

LANCET | 2000年 / 356卷 / 9246期

关键词：

D O I：

10.1016/S0140-6736(00)03312-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The epithelial glycoprotein Ep-CAM is overexpressed in colon cancer and breast cancer. We assessed the frequency and prognostic significance of Ep-CAM in tissue specimens from 205 patients with invasive breast cancer, by immunohistochemical staining with a monoclonal antibody specific for the Ep-CAM antigen. Ep-CAM overexpression was found in 35.6% of samples and was associated with poor disease-free and overall survival.

引用

页码：1981 / 1982

页数：2

共 50 条

[1] Correlation of COX-2 and Ep-CAM overexpression in human invasive breast cancer and its impact on survival
G Spizzo
G Gastl
D Wolf
E Gunsilius
M Steurer
D Fong
A Amberger
R Margreiter
P Obrist
British Journal of Cancer, 2003, 88 : 574 - 578
[2] Prognostic significance of Ep-CAM and Her-2/neu overexpression in invasive breast cancer
Spizzo, G
Obrist, P
Ensinger, C
Theurl, I
Dünser, M
Ramoni, A
Gunsilius, E
Eibl, G
Mikuz, G
Gastl, G
INTERNATIONAL JOURNAL OF CANCER, 2002, 98 (06) : 883 - 888
[3] Cytoplasmic Trop-1/Ep-CAM Overexpression is Associated with a Favorable Outcome in Node-positive Breast Cancer
Alberti, Saverio
Ambrogi, Federico
Boracchi, Patrizia
Fornili, Marco
Querzoli, Patrizia
Pedriali, Massimo
La Sorda, Rossana
Lattanzio, Rossano
Tripaldi, Romina
Piantelli, Mauro
Biganzoli, Elia
Coradini, Danila
JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 2012, 42 (12) : 1128 - 1137
[4] Overexpression of epithelial cell adhesion molecule (Ep-CAM) is an independent prognostic marker for reduced survival of patients with epithelial ovarian cancer
Spizzo, Gilbert
Went, Philip
Dirnhofer, Stephan
Obrist, Peter
Moch, Holger
Baeuerle, Patrick A.
Mueller-Holzner, Elisabeth
Marth, Christian
Gastl, Guenther
Zeimet, Alain G.
GYNECOLOGIC ONCOLOGY, 2006, 103 (02) : 483 - 488
[5] The Ep-CAM: A potential candidate for diagnosis in ovarian cancer
Sawasaki, T.
Katsube, Y.
JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (15)
[6] Validation of the prognostic impact of Ep-CAM in untreated node-negative breast cancer
Schmidt, M.
von Toerne, C.
Boehm, D.
Cotarelo, C.
Lebrecht, A.
Lehr, H.
Koelbl, H.
Gehrmann, M.
Hengstler, J. G.
BREAST, 2009, 18 : S29 - S29
[7] Methylation status of the Ep-CAM promoter region in human breast cancer cell lines and breast cancer tissue
Spizzo, Gilbert
Gastl, Guenther
Obrist, Peter
Fong, Dominic
Haun, Margot
Gruenewald, Kurt
Parson, Walther
Eichmann, Cordula
Millinger, Simone
Fiegl, Heidi
Margreiter, Raimund
Amberger, Albert
CANCER LETTERS, 2007, 246 (1-2) : 253 - 261
[8] Ep-CAM in malignant liver tumours
Ruck, P
Wichert, G
Handgretinger, R
Kaiserling, E
JOURNAL OF PATHOLOGY, 2000, 191 (01): : 102 - 103
[9] High Ep-CAM Expression is Associated with Poor Prognosis in Node-positive Breast Cancer
Gilbert Spizzo
Guenther Gastl
Peter Obrist
Philip Went
Stephan Dirnhofer
Susanne Bischoff
Martina Mirlacher
Guido Sauter
Ronald Simon
Shanna Stopatschinskaya
Philip Haas
Rahel Bart
Ossi Robert Köchli
Hanspeter Spichtin
Robert Maurer
Urs Metzger
Brida von Castelberg
Markus Zuber
Friedrich Mross
Holger Dietrich
Breast Cancer Research and Treatment, 2004, 86 : 207 - 213
[10] High Ep-CAM expression is associated with poor prognosis in node-positive breast cancer
Spizzo, G
Went, P
Dirnhofer, S
Obrist, P
Simon, R
Spichtin, H
Maurer, R
Metzger, U
von Castelberg, B
Bart, R
Stopatschinskaya, S
Köchli, OR
Haas, P
Mross, F
Zuber, M
Dietrich, H
Bischoff, S
Mirlacher, M
Sauter, G
Gastl, G
BREAST CANCER RESEARCH AND TREATMENT, 2004, 86 (03) : 207 - 213

← 1 2 3 4 5 →