Autism Spectrum Disorders: Is Mesenchymal Stem Cell Personalized Therapy the Future?

被引：29
|
作者：
Siniscalco, Dario [1 ,2 ]
Sapone, Anna [3 ,4 ,5 ]
Cirillo, Alessandra [6 ]
Giordano, Catia [1 ]
Maione, Sabatino [1 ]
Antonucci, Nicola [7 ]
机构：
[1] Univ Naples 2, Div Pharmacol L Donatelli, Dept Expt Med, I-80138 Naples, Italy
[2] Ctr Autism, I-80138 Naples, Italy
[3] Univ Naples 2, Dept Internal & Expt Med Magrassi Lanzara, I-80138 Naples, Italy
[4] Univ Maryland, Sch Med, Ctr Celiac Res, Baltimore, MD 21201 USA
[5] Univ Maryland, Sch Med, Mucosal Biol Res Ctr, Baltimore, MD 21201 USA
[6] Univ Naples 2, Div Biotechnol & Mol Biol A Cascino, Dept Expt Med, I-80138 Naples, Italy
[7] Biomed Ctr Autism Res & Treatment, I-70122 Bari, Italy
来源：
JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY | 2012年
关键词：
CHILDREN; BRAIN; TRANSPLANTATION; INTERVENTIONS; GENETICS; CULTURES; DENSITY; GROWTH; ISSUES;
D O I：
10.1155/2012/480289
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Autism and autism spectrum disorders (ASDs) are heterogeneous neurodevelopmental disorders. They are enigmatic conditions that have their origins in the interaction of genes and environmental factors. ASDs are characterized by dysfunctions in social interaction and communication skills, in addition to repetitive and stereotypic verbal and nonverbal behaviours. Immune dysfunction has been confirmed with autistic children. There are no defined mechanisms of pathogenesis or curative therapy presently available. Indeed, ASDs are still untreatable. Available treatments for autism can be divided into behavioural, nutritional, and medical approaches, although no defined standard approach exists. Nowadays, stem cell therapy represents the great promise for the future of molecular medicine. Among the stem cell population, mesenchymal stem cells (MSCs) show probably best potential good results inmedical research. Due to the particular immune and neural dysregulation observed in ASDs, mesenchymal stem cell transplantation could offer a unique tool to provide better resolution for this disease.
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页数：6
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