Development and validation of an analytical method for quantification of metronidazole in pharmaceutical dosage form (vaginal gel)

被引：0

作者：

Bedor, Danilo C. G. ^{[1
]}

Sobrinho, Jose L. Soares ^{[2
]}

Junior, Severino G. ^{[3
]}

Ramos, Selma V. ^{[3
]}

Lima, Adley A. N. ^{[2
]}

Neto, Pedro J. Rolim ^{[2
]}

机构：

[1] NUDFAC UFPE, BR-50740521 Recife, PE, Brazil

[2] Univ Fed Pernambuco, Lab Tecnol Med, BR-50740521 Recife, PE, Brazil

[3] Lab Farmaceut Estado Pernambuco, BR-52171010 Recife, PE, Brazil

来源：

LATIN AMERICAN JOURNAL OF PHARMACY | 2008年 / 27卷 / 02期

关键词：

development of method; metronidazole; validation;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The analytical method of spectrophotometry by UV for the assay of metronidazole vaginal gel was developed and validated following all the requirements of the regulatories agencies. N-N-dimethylformamide was used for the extraction of metronidazole from pharmaceutical form and the wavelength used was 308 rim. The developed method, in accordance with the statistical treatment of the results demonstrated being precise, accurate, selective, robust and linear, consisting a trustworthy and efficient analytical alternative with low cost for determination of metronidazole vaginal gel in the laboratorial routine.

引用

页码：263 / 265

页数：3

共 50 条

[1] Development and validation of analytical method for estimation of cefixime in bulk drug and pharmaceutical dosage form
Jadhav, R. V., 1600, Journal of Chemical and Pharmaceutical Research, 3/668 Malviya Nagar, Jaipur, Rajasthan, India (05):
[2] Development and validation of analytical method for estimation of bilastine in bulk and pharmaceutical (tablet) dosage form
Padte, Chinmayee Kishor
Batwal, Poonam R.
Patil, Mukesh Subhash
Jain, Ashish S.
JOURNAL OF THE INDIAN CHEMICAL SOCIETY, 2021, 98 (11)
[3] Quantification and Stability Indicating UPLC Method Development and Validation of Acalabrutinib in Bulk and Pharmaceutical Dosage Form
Goud, Mohan, V
Singh, Pooja N.
INTERNATIONAL JOURNAL OF LIFE SCIENCE AND PHARMA RESEARCH, 2021, 11 (05): : P41 - P50
[4] Analytical Method Development and Validation of Rivastigmine in its Pure and Pharmaceutical Dosage form Using UPLC
Kommu, Aarthi
Sundararajan, Raja
INTERNATIONAL JOURNAL OF PHARMACEUTICAL INVESTIGATION, 2023, 13 (03) : 595 - 604
[5] ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR THE DETERMINATION OF MIRABEGRON IN PHARMACEUTICAL DOSAGE FORM BY RP-HPLC
Sankar, Panchumarthy Ravi
Kishore, K. Purna
Babji, B.
Sulthana, Md. Shaheem
INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 2020, 11 (05): : 2223 - 2228
[6] Development and Validation of a Green Analytical Method of RP-HPLC for Quantification of Cefepime Hydrochloride in Pharmaceutical Dosage Form: Simple, Sensitive and Economic
Rodrigues, Danilo Fernando
Nunes Salgado, Herida Regina
CURRENT PHARMACEUTICAL ANALYSIS, 2016, 12 (04) : 306 - 314
[7] Development and Validation of the Ultra-Performance Liquid Chromatography Method for Quantification of Belzutifan in Pharmaceutical Dosage Form
Gaddey, Pridhvi Krishna
Sundararajan, Raja
PHARMACEUTICAL CHEMISTRY JOURNAL, 2024, 57 (10) : 1683 - 1692
[8] Development and Validation of the Ultra-Performance Liquid Chromatography Method for Quantification of Belzutifan in Pharmaceutical Dosage Form
Pridhvi Krishna Gaddey
Raja Sundararajan
Pharmaceutical Chemistry Journal, 2024, 57 : 1683 - 1692
[9] METHOD DEVELOPMENT AND VALIDATION FOR THE ESTIMATION OF AMBROXOL HCl IN PHARMACEUTICAL DOSAGE FORM
Prabhu, Padmavathi P.
Das, Paramita
Khushboo, N. Shukla
INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 2018, 9 (06): : 2550 - 2553
[10] Development and Validation of HPTLC Method for Nabumetone from Pharmaceutical Dosage Form
Godse, Vijaya
Mane, S. R.
Vyas, Meenakshi
Bhosale, A.
INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH, 2011, 45 (04) : 301 - 304

← 1 2 3 4 5 →